Department of Bone and Joint Surgery, Ehime University Graduate School of Medicine, Shitsukawa, Toon 791-0295, Ehime, Japan.
Translational Research Center, Ehime University Hospital, Shitsukawa, Toon 791-0295, Ehime, Japan.
Int J Mol Sci. 2017 Sep 13;18(9):1962. doi: 10.3390/ijms18091962.
Despite the availability of several modalities of treatment, including surgery, pharmacological agents, and nerve blocks, neuropathic pain is often unresponsive and sometimes progresses to intractable chronic pain. Although exercise therapy is a candidate for treatment of neuropathic pain, the mechanism underlying its efficacy has not been elucidated. To clarify the molecular mechanism for pain relief induced by exercise, we measured and mRNA levels in the spinal cord dorsal horn of SNL rats, a model of neuropathic pain. SNL model rats exhibited stable mechanical hyperalgesia for at least 6 weeks. When the rats were forced to exercise on a treadmill, mechanical and thermal hyperalgesia were significantly ameliorated compared with the non-exercise group. Accordingly, gene expression level of and were also significantly altered in the time course analysis after surgery. These results suggest that exercise therapy possibly involves pain relief in SNL rats by suppressing and expression in the spinal cord.
尽管有多种治疗方法，包括手术、药物和神经阻滞，但神经病理性疼痛往往没有反应，有时会发展为难治性慢性疼痛。尽管运动疗法是治疗神经病理性疼痛的一种选择，但其疗效的机制尚未阐明。为了阐明运动引起的疼痛缓解的分子机制，我们测量了 SNL 大鼠脊髓背角中的 和 mRNA 水平，SNL 大鼠模型是一种神经病理性疼痛模型。SNL 模型大鼠的机械性痛觉过敏至少稳定 6 周。当大鼠被迫在跑步机上运动时，与非运动组相比，机械性和热痛觉过敏明显改善。因此，手术后的时间过程分析中 基因表达水平也发生了显著改变。这些结果表明，运动疗法可能通过抑制脊髓中 和 的表达来缓解 SNL 大鼠的疼痛。
