HLA - A/B/DRB1基因多态性与再生障碍性贫血之间的关联：来自17项病例对照研究的证据。

Associations between the HLA-A/B/DRB1 polymorphisms and aplastic anemia: evidence from 17 case-control studies.

作者信息

Deng Xiao-Zhen, Du Meng, Peng Jiao, Long Jian-Xiong, Zheng Cheng-Jun, Tan Yuan, Li Li-Juan, Chen Hui-Ying, Qing Cao, Pang Yan-Yan, Lan Yan, Zhang Hai-Tian

机构信息

a Department of Hematology , The First Affiliated Hospital of Guangxi Medical University , Guangxi , China.

b Department of Radiology , The First Affiliated Hospital of Guangxi Medical University , Guangxi , China.

出版信息

Hematology. 2018 Apr;23(3):154-162. doi: 10.1080/10245332.2017.1375064. Epub 2017 Sep 13.

DOI:10.1080/10245332.2017.1375064

PMID:28902578

Abstract

OBJECTIVE

To estimate the associations between HLA-A/B/DRB1 polymorphisms and aplastic anemia (AA), we carried out the meta-analysis.

METHODS

In this meta-analysis, all publications in English and Chinese were considered up to 30 September 2015. The electronic databases we searched were Pubmed, Science Direct, Embase, Web of Science, CNKI, Wanfang Data and VIP. We conducted all statistical data analyses in the Stata11.0 software.

RESULTS

A total of 17 studies including 9164 subjects (containing 1372 cases and 7792 controls) were retrieved, which studied the relationship between HLA-A/B/DRB1 and AA. Odds ratios (ORs) with 95% confidence intervals (CIs) for the comparisons between cases and controls were calculated. The result revealed that HLA-A*02 and HLA-DRB1 (*0407, *15 and *1501) polymorphisms might increase the risk of AA. Otherwise, HLA-DRB1 (*0301, *04, *0406, *0802, *1301, *1302 and *14) were protective against AA. But, other sites of HLA-A/B/DRB1 in our study had no correlations with AA (all P > 0.05).

CONCLUSION

In conclusion, HLA-A/B/DRB1 polymorphisms may play an important role in AA, but higher quality and larger sample studies are needed to confirm.

摘要

目的

为评估人类白细胞抗原A/B/DRB1（HLA-A/B/DRB1）基因多态性与再生障碍性贫血（AA）之间的关联，我们进行了荟萃分析。

方法

在这项荟萃分析中，纳入截至2015年9月30日的所有中英文出版物。我们检索的电子数据库有PubMed、Science Direct、Embase、Web of Science、中国知网、万方数据和维普资讯。我们在Stata11.0软件中进行所有统计数据分析。

结果

共检索到17项研究，包括9164名受试者（其中1372例病例和7792例对照），这些研究探讨了HLA-A/B/DRB1与AA之间的关系。计算病例组与对照组比较的比值比（OR）及其95%置信区间（CI）。结果显示，HLA-A*02以及HLA-DRB1（*0407、15和1501）基因多态性可能增加AA的发病风险。此外，HLA-DRB1（*0301、*04、*0406、*0802、*1301、1302和14）对AA具有保护作用。但是，本研究中HLA-A/B/DRB1的其他位点与AA无相关性（所有P>0.05）。