Henan Institute of Hematology, Department of Hematology, Henan Cancer Hospital Affiliated to Zhengzhou University, Zhengzhou University, Henan Cancer Hospital, Zhengzhou, China.
Department of Oncology, Henan Cancer Hospital Affiliated to Zhengzhou University, Zhengzhou University, Henan Cancer Hospital, Zhengzhou, China.
Medicine (Baltimore). 2023 May 19;102(20):e33513. doi: 10.1097/MD.0000000000033513.
The human leukocyte antigen-DRB1 (HLA-DRB1) gene plays key roles in mediating immune response and activating autoreactive T-cells during aplastic anemia (AA) etiology. However, inconsistency appeared in the associations between HLA-DRB1 polymorphism and AA. We aimed to comprehensively clarify their associations in the meta-analysis.
PubMed, Embase, Web of Science, Science Direct, SinoMed, WanFang Data, China National Knowledge Infrastructure, and Chongqing VIP Chinese Science Database were searched from January 2000 to June 2022. Statistical analysis was performed in STATA 15.0 and Comprehensive Meta-analysis Software 3.0.
A total of 16 studies with 4428 patients were eventually analyzed. The results of the meta-analysis suggested that HLA-DRB10301 could decrease the risk of AA (odd ratio (OR) = 0.600, 95% CI: 0.427, 0.843). Besides, HLA-DRB10901 and HLA-DRB1*1501 were risk factors of AA (OR = 1.591, 95% CI: 1.045, 2.424; OR = 2.145, 95% CI: 1.501, 3.063; respectively). Sensitivity analysis showed heterogeneity among included studies.
HLA-DRB1 polymorphisms could play roles in the occurrence of AA, however more population-based studies with larger sample sizes are required to certify our findings.
人类白细胞抗原-DRB1（HLA-DRB1）基因在介导免疫反应和激活再生障碍性贫血（AA）发病过程中的自身反应性 T 细胞中发挥关键作用。然而，HLA-DRB1 多态性与 AA 之间的关联存在不一致性。我们旨在通过荟萃分析全面阐明它们之间的关联。
从 2000 年 1 月至 2022 年 6 月，我们检索了 PubMed、Embase、Web of Science、Science Direct、SinoMed、万方数据、中国国家知识基础设施和重庆 VIP 中文科学数据库。在 STATA 15.0 和 Comprehensive Meta-analysis Software 3.0 中进行统计分析。
最终分析了 16 项共 4428 例患者的研究。荟萃分析的结果表明，HLA-DRB10301 可降低 AA 的风险（比值比（OR）=0.600，95%CI：0.427，0.843）。此外，HLA-DRB10901 和 HLA-DRB1*1501 是 AA 的危险因素（OR=1.591，95%CI：1.045，2.424；OR=2.145，95%CI：1.501，3.063；分别）。敏感性分析表明纳入研究存在异质性。
HLA-DRB1 多态性可能在 AA 的发生中起作用，但需要更多基于人群的、更大样本量的研究来证实我们的发现。
