香豆素衍生物对人肺癌细胞系的合成与评估
Synthesis and evaluation of coumarin derivatives against human lung cancer cell lines.
作者信息
Weng K-G, Yuan Y-L
机构信息
Department of Radiation Oncology, Chongqing Cancer Institute and Hospital and Cancer Center, Chongqing, China.
Department of Clinical Laboratory, Chongqing the Seventh People's Hospital, Chongqing, China.
出版信息
Braz J Med Biol Res. 2017 Sep 12;50(11):e6455. doi: 10.1590/1414-431X20176455.
Series of novel coumarin derivatives [I (a-d) and II (a-d)] were successfully synthesized and their structures were determined based on infrared 1H-nuclear magnetic resonance (NMR), HRMS, and single crystal X-ray crystallography. Additionally, the new synthesized compounds were evaluated to identify the molecular characteristics that contribute to their cytotoxicity, which was tested against SK-LU-1, SPC-A-1 and 95D human lung cancer cell lines, using the MTT assay. The results of this study showed that compounds Ic, Id, IIc, and IId exhibited an efficient percentage of inhibition of cell proliferation.
成功合成了一系列新型香豆素衍生物[I(a - d)和II(a - d)]，并根据红外光谱、1H - 核磁共振(NMR)、高分辨质谱(HRMS)和单晶X射线晶体学确定了它们的结构。此外，对新合成的化合物进行了评估，以确定有助于其细胞毒性的分子特征，使用MTT法对SK - LU - 1、SPC - A - 1和95D人肺癌细胞系进行了细胞毒性测试。这项研究的结果表明，化合物Ic、Id、IIc和IId表现出对细胞增殖的有效抑制率。
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