Key Laboratory of Functional Food, Ministry of Agriculture, Bio-Tech Research Institute, Guangdong Academy of Agricultural Sciences, Guangzhou 510610, China.
Molecules. 2011 Dec 13;16(12):10324-36. doi: 10.3390/molecules161210324.
The immunomodulatory function of longan pulp polysaccharide-protein complex (LP3) was investigated in immunosuppressed mice models. Compared with the model control, peroral administration of 100 mgkg⁻¹d⁻¹ LP3 could significantly increase/enhance antibody production against chicken red blood cell (CRBC), concanavalin A (ConA)-induced splenocyte proliferation, macrophage phagocytosis, NK cell cytotoxicity against YAC-1 lymphoma cell, and interferon-gamma (INF-γ) and interleukin-2 (IL-2) secretion in serum (P < 0.05). The immunomodulatory effects, except for those on splenocytes and macrophages (P > 0.05), were also observed in mice administered with 50 or 200 mgkg⁻¹d⁻¹ LP3 (P < 0.05). The beneficial effects of 50-200 mgkg⁻¹d⁻¹ LP3 were comparable to those of 50 mgkg⁻¹d⁻¹ ganoderan. The strong immunomodulatory activity of LP3 confirmed its good potential as an immunotherapeutic adjuvant.
龙眼果肉多糖蛋白复合物（LP3）的免疫调节功能在免疫抑制小鼠模型中进行了研究。与模型对照组相比，100mg/kg/d 的 LP3 口服给药可显著增加/增强针对鸡红细胞（CRBC）的抗体产生、刀豆蛋白 A（ConA）诱导的脾细胞增殖、巨噬细胞吞噬作用、NK 细胞对 YAC-1 淋巴瘤细胞的细胞毒性以及血清中干扰素-γ（INF-γ）和白细胞介素-2（IL-2）的分泌（P < 0.05）。在给予 50 或 200mg/kg/d LP3 的小鼠中，除了对脾细胞和巨噬细胞的作用（P > 0.05）外，还观察到免疫调节作用（P < 0.05）。50-200mg/kg/d LP3 的有益作用与 50mg/kg/d 灵芝多糖相当。LP3 的强免疫调节活性证实了其作为免疫治疗佐剂的良好潜力。
