Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
J Cell Mol Med. 2023 Oct;27(19):2841-2863. doi: 10.1111/jcmm.17936. Epub 2023 Sep 12.
The most common type of cancer in the world is lung cancer. Traditional treatments have an important role in cancer therapy. In the present review, the most recent findings on the effects of medicinal plants and their constituents or natural products (NP) in treating lung cancer are discussed. Empirical studies until the end of March 2022 were searched using the appropriate keywords through the databases PubMed, Science Direct and Scopus. The extracts and essential oils tested were all shown to effect lung cancer by several mechanisms including decreased tumour weight and volume, cell viability and modulation of cytokine. Some plant constituents increased expression of apoptotic proteins, the proportion of cells in the G2/M phase and subG0/G1 phase, and Cyt c levels. Also, natural products (NP) activate apoptotic pathways in lung cancer cell including p-JNK, Akt/mTOR, PI3/ AKT\ and Bax, Bcl2, but suppressed AXL phosphorylation. Plant-derived substances altered the cell morphology, reduced cell migration and metastasis, oxidative marker production, p-eIF2α and GRP78, IgG, IgM levels and reduced leukocyte counts, LDH, GGT, 5'NT and carcinoembryonic antigen (CEA). Therefore, medicinal plant extracts and their constituents could have promising therapeutic value for lung cancer, especially if used in combination with ordinary anti-cancer drugs.
世界上最常见的癌症是肺癌。传统治疗在癌症治疗中具有重要作用。在本次综述中，讨论了药用植物及其成分或天然产物（NP）在治疗肺癌方面的最新发现。截至 2022 年 3 月底，使用适当的关键词通过 PubMed、Science Direct 和 Scopus 数据库搜索了经验性研究。测试的提取物和精油都通过多种机制显示出对肺癌的作用，包括减少肿瘤重量和体积、细胞活力和细胞因子的调节。一些植物成分增加了促凋亡蛋白的表达、G2/M 期和 subG0/G1 期细胞的比例以及 Cyt c 水平。此外，天然产物（NP）在肺癌细胞中激活促凋亡途径，包括 p-JNK、Akt/mTOR、PI3/AKT 和 Bax、Bcl2，但抑制了 AXL 磷酸化。植物衍生物质改变了细胞形态，减少了细胞迁移和转移、氧化标志物的产生、p-eIF2α 和 GRP78、IgG、IgM 水平，并降低了白细胞计数、LDH、GGT、5'NT 和癌胚抗原（CEA）。因此，药用植物提取物及其成分可能对肺癌具有有前途的治疗价值，特别是如果与普通抗癌药物联合使用。
