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Retromer Binding to FAM21 and the WASH Complex Is Perturbed by the Parkinson Disease-Linked VPS35(D620N) Mutation.与帕金森病相关的VPS35（D620N）突变会干扰Retromer与FAM21和WASH复合物的结合。
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2
Retromer binding to FAM21 and the WASH complex is perturbed by the Parkinson disease-linked VPS35(D620N) mutation.与帕金森病相关的VPS35（D620N）突变会干扰Retromer与FAM21及WASH复合体的结合。
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Retromer-mediated recruitment of the WASH complex involves discrete interactions between VPS35, VPS29, and FAM21.Retromer 介导的 WASH 复合物的募集涉及 VPS35、VPS29 和 FAM21 之间的离散相互作用。
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Formation of retromer transport carriers is disrupted by the Parkinson disease-linked Vps35 D620N variant.帕金森病相关 Vps35 D620N 变异破坏了 retromer 转运载体的形成。
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Endosomal traffic and glutamate synapse activity are increased in VPS35 D620N mutant knock-in mouse neurons, and resistant to LRRK2 kinase inhibition.内体运输和谷氨酸突触活性在 VPS35 D620N 突变敲入小鼠神经元中增加，并能抵抗 LRRK2 激酶抑制。
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The Vps35 D620N mutation linked to Parkinson's disease disrupts the cargo sorting function of retromer.与帕金森病相关的 Vps35 D620N 突变破坏了 retromer 的货物分拣功能。
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VPS35 and retromer dysfunction in Parkinson's disease.VPS35 和 retromer 功能障碍与帕金森病。
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Recruitment of the endosomal WASH complex is mediated by the extended 'tail' of Fam21 binding to the retromer protein Vps35.网格蛋白包被小泡形成复合物的招募是由 Fam21 蛋白的延伸“尾巴”与再循环蛋白 Vps35 结合介导的。
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引用本文的文献

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Identification of a VPS29 isoform with restricted association to Retriever and Retromer accessory proteins through autoinhibition.通过自抑制鉴定一种与Retriever和Retromer辅助蛋白关联受限的VPS29亚型。
Proc Natl Acad Sci U S A. 2025 Jul 8;122(27):e2501111122. doi: 10.1073/pnas.2501111122. Epub 2025 Jun 30.
2
γ-secretase facilitates retromer-mediated retrograde transport.γ-分泌酶促进retromer介导的逆向运输。
J Cell Sci. 2025 Feb 15;138(4). doi: 10.1242/jcs.263538. Epub 2025 Feb 20.
3
γ-secretase facilitates retromer-mediated retrograde transport.γ-分泌酶促进回收体介导的逆向运输。
bioRxiv. 2024 Jun 7:2024.06.07.597932. doi: 10.1101/2024.06.07.597932.
4
Retromer-mediated recruitment of the WASH complex involves discrete interactions between VPS35, VPS29, and FAM21.Retromer 介导的 WASH 复合物的募集涉及 VPS35、VPS29 和 FAM21 之间的离散相互作用。
Protein Sci. 2024 May;33(5):e4980. doi: 10.1002/pro.4980.
5
Key genes and convergent pathogenic mechanisms in Parkinson disease.帕金森病的关键基因和趋同发病机制。
Nat Rev Neurosci. 2024 Jun;25(6):393-413. doi: 10.1038/s41583-024-00812-2. Epub 2024 Apr 10.
6
Protein sorting from endosomes to the TGN.蛋白质从内体到反式高尔基体网络的分选
Front Cell Dev Biol. 2023 Feb 21;11:1140605. doi: 10.3389/fcell.2023.1140605. eCollection 2023.
7
Mechanisms of -Mediated Neurodegeneration in Parkinson's Disease.帕金森病中α-突触核蛋白介导神经退行性变的机制
Int Rev Mov Disord. 2021;2:221-244. doi: 10.1016/bs.irmvd.2021.08.005. Epub 2021 Sep 30.
8
Retrograde transport of CDMPR depends on several machineries as analyzed by sulfatable nanobodies.经可磺化纳米抗体分析，CDMPR 的逆行转运依赖于几种机制。
Life Sci Alliance. 2022 Mar 21;5(7). doi: 10.26508/lsa.202101269. Print 2022 Mar.
9
Endosomal Recycling Defects and Neurodevelopmental Disorders.内体循环缺陷与神经发育障碍
Cells. 2022 Jan 3;11(1):148. doi: 10.3390/cells11010148.
10
Architecture and mechanism of metazoan retromer:SNX3 tubular coat assembly.后生动物回收体的结构与机制：分选衔接蛋白3管状衣被组装
Sci Adv. 2021 Mar 24;7(13). doi: 10.1126/sciadv.abf8598. Print 2021 Mar.

Retromer Binding to FAM21 and the WASH Complex Is Perturbed by the Parkinson Disease-Linked VPS35(D620N) Mutation.

作者信息

McGough Ian J, Steinberg Florian, Jia Da, Barbuti Peter A, McMillan Kirsty J, Heesom Kate J, Whone Alan L, Caldwell Maeve A, Billadeau Daniel D, Rosen Michael K, Cullen Peter J

机构信息

The Henry Wellcome Integrated Signaling Laboratories, School of Biochemistry, Medical Sciences Building, University of Bristol, Bristol BS8 1TD, UK.

Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

出版信息

Curr Biol. 2014 Jul 21;24(14):1678. doi: 10.1016/j.cub.2014.07.004.

DOI:10.1016/j.cub.2014.07.004
PMID:28903028
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5628949/
Abstract
摘要