Raoux Matthieu, Rodat-Despoix Lise, Azorin Nathalie, Giamarchi Aurélie, Hao Jizhe, Maingret François, Crest Marcel, Coste Bertrand, Delmas Patrick
Laboratoire de Neurophysiologie Cellulaire, Centre National de la Recherche Scientifique UMR 6150, Université de la Méditerranée, Marseille, France.
Sensors (Basel). 2007 Sep 3;7(9):1667-1682. doi: 10.3390/s7091667.
Mechanoreceptive sensory neurons innervating the skin, skeletal muscles andviscera signal both innocuous and noxious information necessary for proprioception, touchand pain. These neurons are responsible for the transduction of mechanical stimuli intoaction potentials that propagate to the central nervous system. The ability of these cells todetect mechanical stimuli impinging on them relies on the presence of mechanosensitivechannels that transduce the external mechanical forces into electrical and chemical signals.Although a great deal of information regarding the molecular and biophysical properties ofmechanosensitive channels in prokaryotes has been accumulated over the past two decades,less is known about the mechanosensitive channels necessary for proprioception and thesenses of touch and pain. This review summarizes the most pertinent data onmechanosensitive channels of mammalian somatosensory neurons, focusing on theirproperties, pharmacology and putative identity.
支配皮肤、骨骼肌和内脏的机械感受性感觉神经元传递本体感觉、触觉和痛觉所需的无害和有害信息。这些神经元负责将机械刺激转化为动作电位，并传播到中枢神经系统。这些细胞检测施加于其上的机械刺激的能力依赖于机械敏感通道的存在，这些通道将外部机械力转化为电信号和化学信号。尽管在过去二十年里已经积累了大量关于原核生物机械敏感通道的分子和生物物理特性的信息，但对于本体感觉以及触觉和痛觉所需的机械敏感通道却知之甚少。本综述总结了关于哺乳动物体感神经元机械敏感通道的最相关数据，重点关注其特性、药理学及假定的身份。
