Omerbašić Damir, Schuhmacher Laura-Nadine, Bernal Sierra Yinth-Andrea, Smith Ewan St John, Lewin Gary R
Department of Neuroscience, Max Delbrück Center for Molecular Medicine, Robert-Rössle Straße 10, D-13125 Berlin, Germany.
Dept. of Pharmacology, University of Cambridge, Tennis Court Rd., Cambridge CB2 1PD, United Kingdom.
Neuropharmacology. 2015 Jul;94:80-6. doi: 10.1016/j.neuropharm.2014.12.007. Epub 2014 Dec 18.
It is well established that some members of the Deg/ENaC super family of amiloride sensitive ion channels can participate directly in the transduction of mechanical stimuli by sensory neurons in invertebrates. A large body of work has also implicated the acid sensing ion channels family (ASIC1-4) as participants in regulating mechanoreceptor sensitivity in vertebrates. In this review we provide an overview of the physiological and genetic evidence for involvement of ASICs in mechanosensory function. On balance, the available evidence favors the idea that these channels have an important regulatory role in mechanosensory function. It is striking how diverse the consequences of Asic gene deletion are on mechanosensory function with both gain and loss of function effects being observed depending on sensory neuron type. We conclude that other, as yet unknown, molecular partners of ASIC proteins may be decisive in determining their precise physiological role in mechanosensory neurons. This article is part of the Special Issue entitled 'Acid-Sensing Ion Channels in the Nervous System'.
已充分证实，阿米洛利敏感离子通道的Deg/ENaC超家族的一些成员可直接参与无脊椎动物感觉神经元对机械刺激的转导。大量研究还表明，酸敏感离子通道家族（ASIC1 - 4）参与调节脊椎动物的机械感受器敏感性。在本综述中，我们概述了ASICs参与机械感觉功能的生理学和遗传学证据。总的来说，现有证据支持这些通道在机械感觉功能中具有重要调节作用这一观点。值得注意的是，根据感觉神经元类型的不同，Asic基因缺失对机械感觉功能的影响多种多样，既有功能增强的效应，也有功能丧失的效应。我们得出结论，ASIC蛋白的其他尚未知晓的分子伴侣可能在决定它们在机械感觉神经元中的确切生理作用方面起决定性作用。本文是名为“神经系统中的酸敏感离子通道”的特刊的一部分。
