Lou H C, Edvinsson L, MacKenzie E T
Kennedy Institute, Glostrup, Denmark.
Ann Neurol. 1987 Sep;22(3):289-97. doi: 10.1002/ana.410220302.
A tight coupling exists between brain function and cerebral perfusion in most situations. The Roy and Sherrington hypothesis has been widely accepted to account for the phenomenon: increased neuronal metabolic activity will give rise to the accumulation of vasoactive catabolites, which decrease vascular resistance and thereby increase blood flow until normal homeostasis is reestablished. However, the hypothesis does not account for the disproportionate increase in flow that occurs in a number of circumstances. There are additional difficulties in reconciling more recent experimental data with the Roy and Sherrington hypothesis. In this review we direct attention toward the rich perivascular nerve supply to all parts of the cerebral circulation as possibly being an alternative control system allowing for rapid parallel changes in flow and neuronal activity.
在大多数情况下，脑功能与脑灌注之间存在紧密耦合。罗伊和谢灵顿假说已被广泛接受来解释这一现象：神经元代谢活动增加会导致血管活性分解代谢产物的积累，这些产物会降低血管阻力，从而增加血流量，直到重新建立正常的内环境稳定。然而，该假说无法解释在许多情况下出现的不成比例的血流增加。将更多近期实验数据与罗伊和谢灵顿假说相协调还存在其他困难。在本综述中，我们将注意力转向脑循环各部分丰富的血管周围神经供应，认为其可能是一个替代控制系统，能够使血流和神经元活动迅速并行变化。
