Mex3a expression and survival analysis of bladder urothelial carcinoma.

OBJECTIVE

Bladder urothelial carcinoma is a common tumor in humans and a multifactorial disease. The gene is associated with tumor formation and may promote cell proliferation and migration. Therefore, this study aimed to determine the relationship between and bladder urothelial carcinoma.

METHODS

The clinical and RNA sequencing expression data in patients with bladder urothelial carcinoma were downloaded from the The Cancer Genome Atlas data portal. A total of 412 bladder urothelial carcinoma samples were available in the database, for which the clinical information was acquired, of which 412 are RNA sequencing samples with a total of 19 paired samples. Univariate and multivariate Cox analyses and univariate logistic regression analysis were conducted using the software SPSS version 22.0 and <0.05 was considered statistically significant.

RESULTS

The results of the independent -test of 19 paired samples indicated that the expression level of was significantly higher in tumor tissues compared with adjacent normal tissues. expression as a categorical dependent variable was not associated with overall survival, and the overall survival of bladder urothelial carcinoma was associated with the group of age, cancer status, lymphatic vascular invasion, pathological stage, pathological size, and pathological lymph metastasis. The multivariable Cox model adjusted for the group of expression level, age, gender, tumor status, and pathological stage showed that only the age and cancer status groups were associated with the overall survival.

CONCLUSION

expression was not a poor prognostic factor of bladder urothelial carcinoma. Moreover, the expression levels of in the papillary type of bladder urothelial carcinoma were higher than those of the non-papillary type.