双功能蛋白MEX3A的致癌潜力
Oncogenic Potential of the Dual-Function Protein MEX3A.
作者信息
Lederer Marcell, Müller Simon, Glaß Markus, Bley Nadine, Ihling Christian, Sinz Andrea, Hüttelmaier Stefan
机构信息
Charles Tanford Protein Center, Faculty of Medicine, Institute of Molecular Medicine, Section for Molecular Cell Biology, Martin Luther University Halle-Wittenberg, Kurt-Mothes-Str. 3a, 06120 Halle, Germany.
Center for Structural Mass Spectrometry, Department of Pharmaceutical Chemistry & Bioanalytics, Institute of Pharmacy, Martin Luther University Halle-Wittenberg, Kurt-Mothes-Str. 3, 06120 Halle (Saale), Germany.
出版信息
Biology (Basel). 2021 May 7;10(5):415. doi: 10.3390/biology10050415.
MEX3A belongs to the MEX3 (Muscle EXcess) protein family consisting of four members (MEX3A-D) in humans. Characteristic for MEX3 proteins is their domain structure with 2 HNRNPK homology (KH) domains mediating RNA binding and a C-terminal really interesting new gene (RING) domain that harbors E3 ligase function. In agreement with their domain composition, MEX3 proteins were reported to modulate both RNA fate and protein ubiquitination. MEX3 paralogs exhibit an oncofetal expression pattern, they are severely downregulated postnatally, and re-expression is observed in various malignancies. Enforced expression of MEX3 proteins in various cancers correlates with poor prognosis, emphasizing their oncogenic potential. The latter is supported by MEX3A's impact on proliferation, self-renewal as well as migration of tumor cells in vitro and tumor growth in xenograft studies.
MEX3A属于MEX3（肌肉过量）蛋白家族，该家族在人类中有四个成员（MEX3A - D）。MEX3蛋白的特征在于其结构域结构，具有2个介导RNA结合的HNRNPK同源（KH）结构域和一个具有E3连接酶功能的C末端真核生物中非常有趣的新基因（RING）结构域。与它们的结构域组成一致，据报道MEX3蛋白可调节RNA命运和蛋白质泛素化。MEX3旁系同源物表现出癌胚表达模式，它们在出生后严重下调，并且在各种恶性肿瘤中观察到重新表达。在各种癌症中强制表达MEX3蛋白与预后不良相关，强调了它们的致癌潜力。后者得到了MEX3A对体外肿瘤细胞增殖、自我更新以及迁移以及异种移植研究中肿瘤生长的影响的支持。
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