Departments of1Pharmacy.
Epidemiology and Biostatistics.
J Pediatric Infect Dis Soc. 2017 Sep 1;6(3):e149-e151. doi: 10.1093/jpids/pix058.
Limited data on optimal posaconazole dosing strategies for pediatric patients exist. In this study, we found that the median initial dose in patients who achieved a posaconazole plasma concentration of 0.7 μg/mL was 22.8 mg/kg per day whereas the median initial dose in those who did not reach the target concentration was 15.8 mg/kg per day; this result suggests that higher initial doses might be warranted.
关于儿童患者最佳泊沙康唑给药方案的数据有限。本研究发现，达到泊沙康唑血药浓度 0.7μg/ml 的患者的中位起始剂量为 22.8mg/kg/天，而未达到目标浓度的患者的中位起始剂量为 15.8mg/kg/天；这表明较高的初始剂量可能是必要的。
