Ndikuryayo Ferdinand, Moosavi Behrooz, Yang Wen-Chao, Yang Guang-Fu
Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, College of Chemistry, Central China Normal University , Wuhan 430079, P. R. China.
Collaborative Innovation Center of Chemical Science and Engineering , Tianjin 30071, P. R. China.
J Agric Food Chem. 2017 Oct 4;65(39):8523-8537. doi: 10.1021/acs.jafc.7b03851. Epub 2017 Sep 25.
The development of new herbicides is receiving considerable attention to control weed biotypes resistant to current herbicides. Consequently, new enzymes are always desired as targets for herbicide discovery. 4-Hydroxyphenylpyruvate dioxygenase (HPPD, EC 1.13.11.27) is an enzyme engaged in photosynthetic activity and catalyzes the transformation of 4-hydroxyphenylpyruvic acid (HPPA) into homogentisic acid (HGA). HPPD inhibitors constitute a promising area of discovery and development of innovative herbicides with some advantages, including excellent crop selectivity, low application rates, and broad-spectrum weed control. HPPD inhibitors have been investigated for agrochemical interests, and some of them have already been commercialized as herbicides. In this review, we mainly focus on the chemical biology of HPPD, discovery of new potential inhibitors, and strategies for engineering transgenic crops resistant to current HPPD-inhibiting herbicides. The conclusion raises some relevant gaps for future research directions.
新型除草剂的研发备受关注，旨在控制对现有除草剂产生抗性的杂草生物型。因此，人们一直期望发现新的酶作为除草剂研发的靶点。4-羟基苯丙酮酸双加氧酶（HPPD，EC 1.13.11.27）是一种参与光合作用的酶，催化4-羟基苯丙酮酸（HPPA）转化为尿黑酸（HGA）。HPPD抑制剂是创新型除草剂发现与开发的一个有前景的领域，具有一些优势，包括优异的作物选择性、低施用量和广谱杂草防除效果。出于农用化学品方面的兴趣，人们对HPPD抑制剂进行了研究，其中一些已作为除草剂实现商业化。在本综述中，我们主要关注HPPD的化学生物学、新的潜在抑制剂的发现以及培育抗现有HPPD抑制型除草剂转基因作物的策略。结论提出了未来研究方向的一些相关差距。
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