Einstein R, Mihailidou A S, Richardson D P
Department of Pharmacology, University of Sydney, N.S.W., Australia.
Br J Pharmacol. 1987 Oct;92(2):445-50. doi: 10.1111/j.1476-5381.1987.tb11341.x.
1 The cardiovascular effects of histamine were examined in dogs anaesthetized with pentobarbitone 2 The effect of histamine on heart rate, blood pressure, left ventricular pressure, dP/dtmax and dP/dt: IIT (integrated isometric tension) was compared in the presence and absence of autonomic reflexes and blood pressure control. 3 In innervated animals with no attempt to control blood pressure, histamine produced dose-dependent decreases in blood pressure and heart rate and either positive or negative inotropic actions. 4 When autonomic reflexes were abolished, this variability in inotropic response was reduced and histamine produced a slight positive inotropic response. There was a decrease in blood pressure and a positive chronotropic response to histamine. 5 When blood pressure was controlled and the cardiac nerves were intact, histamine produced a decrease in heart rate. However, in the denervated animals, there was a slight increase in heart rate. 6 Inotropic responses to histamine in the blood pressure controlled groups were less variable than when blood pressure was uncontrolled. In all of these animals there was an increase in contractility, the increase being more marked in the denervated group. 7 The H2-receptor agonist impromidine produced a positive inotropic action in intact animals with uncontrolled blood pressure.
在用戊巴比妥麻醉的犬中研究了组胺对心血管系统的作用。
在有或无自主反射及血压控制的情况下，比较了组胺对心率、血压、左心室压力、dP/dtmax和dP/dt：IIT（等长张力积分）的影响。
在未试图控制血压的有神经支配的动物中，组胺使血压和心率呈剂量依赖性降低，并产生正性或负性肌力作用。
当自主反射被消除时，这种肌力反应的变异性降低，组胺产生轻微的正性肌力反应。对组胺有血压降低和正性变时反应。
当血压得到控制且心脏神经完整时，组胺使心率降低。然而，在去神经支配的动物中，心率略有增加。
血压控制组对组胺的肌力反应比血压未控制时变异性小。在所有这些动物中，收缩力增加，在去神经支配组中增加更为明显。
H2受体激动剂英普咪定在血压未控制的完整动物中产生正性肌力作用。
