Office of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
Office of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA.
J Clin Microbiol. 2017 Nov;55(11):3267-3282. doi: 10.1128/JCM.01013-17. Epub 2017 Sep 13.
The TB Portals program is an international consortium of physicians, radiologists, and microbiologists from countries with a heavy burden of drug-resistant tuberculosis working with data scientists and information technology professionals. Together, we have built the TB Portals, a repository of socioeconomic/geographic, clinical, laboratory, radiological, and genomic data from patient cases of drug-resistant tuberculosis backed by shareable, physical samples. Currently, there are 1,299 total cases from five country sites (Azerbaijan, Belarus, Moldova, Georgia, and Romania), 976 (75.1%) of which are multidrug or extensively drug resistant and 38.2%, 51.9%, and 36.3% of which contain X-ray, computed tomography (CT) scan, and genomic data, respectively. The top lineages represented among collected samples are Beijing, T1, and H3, and single nucleotide polymorphisms (SNPs) that confer resistance to isoniazid, rifampin, ofloxacin, and moxifloxacin occur the most frequently. These data and samples have promoted drug discovery efforts and research into genomics and quantitative image analysis to improve diagnostics while also serving as a valuable resource for researchers and clinical providers. The TB Portals database and associated projects are continually growing, and we invite new partners and collaborations to our initiative. The TB Portals data and their associated analytical and statistical tools are freely available at https://tbportals.niaid.nih.gov/.
TB 门户计划是一个由来自耐药结核病负担沉重国家的医生、放射科医生和微生物学家组成的国际联盟，他们与数据科学家和信息技术专业人员合作。我们共同建立了 TB 门户，这是一个包含耐药结核病患者的社会经济/地理位置、临床、实验室、放射学和基因组数据的存储库，这些数据由可共享的物理样本支持。目前，有来自五个国家（阿塞拜疆、白俄罗斯、摩尔多瓦、格鲁吉亚和罗马尼亚）的 1299 例总病例，其中 976 例（75.1%）为耐多药或广泛耐药，分别有 38.2%、51.9%和 36.3%的病例包含 X 射线、计算机断层扫描（CT）扫描和基因组数据。在所收集的样本中，代表的主要谱系是北京、T1 和 H3，并且最常出现与异烟肼、利福平、氧氟沙星和莫西沙星耐药相关的单核苷酸多态性（SNP）。这些数据和样本促进了药物发现工作以及基因组学和定量图像分析的研究，以改善诊断，同时也为研究人员和临床医生提供了有价值的资源。TB 门户数据库及其相关项目正在不断发展，我们邀请新的合作伙伴和合作关系加入我们的倡议。TB 门户数据及其相关的分析和统计工具可在 https://tbportals.niaid.nih.gov/ 免费获得。
