Chauduri Jaydip Ray, Mridula K Rukmini, Umamashesh Matapathi, Balaraju Banda, Bandaru V C S Srinivasarao
Department of Neurology, Yashoda Hospital, Hyderabad, Telangana, India.
Department of Neurology, Nizam's Institution of Medical Sciences, Hyderabad, Telangana, India.
Ann Indian Acad Neurol. 2017 Jul-Sep;20(3):242-247. doi: 10.4103/aian.AIAN_37_17.
Abnormal carotid intima-media thickness (IMT) is a marker of carotid atherosclerosis which is a risk factor for cerebrovascular and cardiovascular diseases. Recent studies have found an association of 25-hydroxyvitamin D deficiency with abnormal carotid IMT.
The purpose of the study was to investigate the association of serum 25-hydroxyvitamin D levels with carotid IMT in Indian participants.
We prospectively recruited 300 participants at Yashoda Hospital, Hyderabad, during the study period between January 2012 and December 2014. All participants were assessed for fasting blood sugar, lipid profile, C-reactive protein (CRP), serum alkaline phosphatase, serum calcium, serum phosphorous, serum 25-hydroxyvitamin D levels, and carotid Doppler examination.
Among the 300 participants, men were 190 (63.3%) and mean age was 51.9 ± 7.7 years with a range from 35 to 64 years. On risk factors evaluation, 105 (35%) were hypertensive, 79 (26.3%) diabetics, 63 (21%) smokers, and 56 (18.6%) were alcoholics. On evaluation of biochemical parameters, 81 (27%) had dyslipidemia, 120 (40%) had elevated CRP levels, 119 (39.6%) had 25-hydroxyvitamin D deficiency, mean alkaline phosphatase was 93.9 ± 14.9 IU/L, serum calcium (mg/dL) was 9.2 ± 2.3, and serum phosphorous 4.4 ± 1.2 mg/dL. On carotid imaging, 121 (40.3%) had abnormal IMT. After multivariate analysis, 25-hydroxyvitamin D deficiency (odds ratio [OR]: 2.14; 95% confidence interval [CI]: 1.29-3.55), dyslipidemia (OR: 2.53; 95% CI: 1.46-4.40), elevated CRP (OR: 2.27; 95% CI: 1.37-3.76), smoking (OR: 2.09; 95% CI: 1.16-3.77), and diabetes (OR: 1.84; 95% CI: 1.05-3.21) were independently associated with abnormal IMT.
In our study, we established 25-hydroxyvitamin D deficiency as an independently associated with abnormal IMT in Indian participants.
颈动脉内膜中层厚度（IMT）异常是颈动脉粥样硬化的一个标志，而颈动脉粥样硬化是脑血管疾病和心血管疾病的一个危险因素。最近的研究发现25-羟维生素D缺乏与颈动脉IMT异常有关。
本研究的目的是调查印度参与者血清25-羟维生素D水平与颈动脉IMT之间的关联。
在2012年1月至2014年12月的研究期间，我们在海得拉巴的亚肖达医院前瞻性招募了300名参与者。所有参与者均接受空腹血糖、血脂谱、C反应蛋白（CRP）、血清碱性磷酸酶、血清钙、血清磷、血清25-羟维生素D水平以及颈动脉多普勒检查。
在300名参与者中，男性有190名（63.3%），平均年龄为51.9±7.7岁，范围为35至64岁。在危险因素评估中，105名（35%）患有高血压，79名（26.3%）患有糖尿病，63名（21%）吸烟，56名（18.6%）酗酒。在生化参数评估中，81名（27%）患有血脂异常，120名（40%）CRP水平升高，119名（39.6%）有25-羟维生素D缺乏，平均碱性磷酸酶为93.9±14.9 IU/L，血清钙（mg/dL）为9.2±2.3，血清磷为4.4±1.2 mg/dL。在颈动脉成像检查中，121名（40.3%）IMT异常。多因素分析后，25-羟维生素D缺乏（比值比[OR]：2.14；95%置信区间[CI]：1.29 - 3.55）、血脂异常（OR：2.53；95%C：1.46 - 4.40）、CRP升高（OR：2.27；95%CI：1.37 - 3.76）、吸烟（OR：2.09；95%CI：1.16 - 3.77）和糖尿病（OR：1.84；95%CI：1.05 - 3.21）均与IMT异常独立相关。
在我们的研究中，我们确定25-羟维生素D缺乏与印度参与者的IMT异常独立相关。
