Correlation of Site of Embryo Transfer with IVF Outcome: Analysis of 743 Cycles from a Single Center.

OBJECTIVE

To investigate the influence of site of embryo transfer (ET) on reproductive outcome.

MATERIALS AND METHODS

A retrospective analysis of 743 ultrasound-guided ET in fresh fertilization (IVF) cycles from a single center over a period of 4 years was conducted. The distance between the fundal endometrial surface and the air bubble was measured, and accordingly, patients were divided into four groups (≤10 mm; >10 and ≤15 mm; >15 and 20 mm; >20 and <25 mm).

SETTING

Tertiary Assisted Reproductive Technology (ART) center.

PATIENTS

All patients enrolled in the IVF program undergoing ET.

INTERVENTIONS

Controlled ovarian hyperstimulation (OS), IVF, and ET.

MAIN OUTCOME MEASURES

Cleavage rate and clinical pregnancy rate.

RESULTS

Clinical pregnancy rate was significantly more in groups 2 and 3 compared to the other groups. Logistic regression analysis showed that one unit increase in embryos transfer will enhance the pregnancy outcome about 3.7 (adjusted odds ratio) times with 95% confidence limits 2.6 to 5.4. Similarly, pregnancy outcome will be 3.1 (95% confidence limits: 1.5-6.4) times higher for distance group >15 and <20 mm compared to less than 10-mm distance group. Ectopic pregnancy rates were similar in all the four groups.

CONCLUSION

The present study demonstrates that site of ET has significant difference on reproductive outcome.