Yimam Mesfin, Horm Teresa, Wright Laura, Jiao Ping, Hong Mei, Brownell Lidia, Jia Qi
Unigen Inc., 3005 1st Ave., Seattle, WA 98121, USA.
Evid Based Complement Alternat Med. 2017;2017:7059068. doi: 10.1155/2017/7059068. Epub 2017 Aug 20.
Although there have been augmented advances in drug discovery, current OA management is inadequate due to the lack of successful therapies proven to be effective in modifying disease progression. For some, the risk outweighs the benefit. As a result, there is a desperate need for safe and efficacious natural alternatives. Here we evaluated a composition from , , and in maintaining joint structural integrity and alleviating OA associated symptoms in monoiodoacetate- (MIA-) induced rat OA disease model. Study lasted for 6 weeks. 59.6%, 64.6%, 70.7%, 69.9%, and 70.3% reductions in pain sensitivity were observed for rats treated with the composition from week 1 to week 5, respectively. Statistically significant improvements in articular cartilage matrix integrity (maintained at 57.1% versus MIA + vehicle treated rats) were shown from the modified total Mankin score for animals treated with the composition. The composition showed a statistically significant reduction in uCTX-II level (54.1% reductions). The merit of combining these botanicals was also demonstrated in their synergistic analgesic activity. Therefore, the standardized blend of , , and could potentially be considered as an alternative remedy from natural sources for the management of OA and/or its associated symptoms.
尽管药物研发取得了显著进展，但由于缺乏经证实能有效改变疾病进展的成功疗法，目前骨关节炎（OA）的治疗仍不充分。对一些人来说，风险大于益处。因此，迫切需要安全有效的天然替代方案。在此，我们评估了一种由[植物名称1]、[植物名称2]和[植物名称3]组成的组合物在单碘乙酸盐（MIA）诱导的大鼠骨关节炎疾病模型中维持关节结构完整性和减轻OA相关症状的效果。研究持续了6周。分别观察到用该组合物处理的大鼠从第1周 到第5周疼痛敏感性降低了59.6%、64.6%、70.7%、69.9%和70.3%。从用该组合物处理的动物的改良总曼金评分来看，关节软骨基质完整性有统计学意义的改善（与MIA + 赋形剂处理的大鼠相比维持在57.1%）。该组合物显示出uCTX-II水平有统计学意义的降低（降低了54.1%）。这些植物药组合的优点还体现在它们的协同镇痛活性上。因此，[植物名称1]、[植物名称2]和[植物名称3]的标准化混合物有可能被视为一种来自天然来源的替代疗法，用于管理OA和/或其相关症状。
