2013 年骨关节炎研究回顾：生物学。
Osteoarthritis year in review 2013: biology.
机构信息
Department of Internal Medicine, Section of Molecular Medicine and The Wake Forest Arthritis and Musculoskeletal Diseases Research Center, Wake Forest School of Medicine, Winston-Salem, NC, USA.
出版信息
Osteoarthritis Cartilage. 2013 Oct;21(10):1436-42. doi: 10.1016/j.joca.2013.05.020. Epub 2013 Jun 14.
Abstract
The purpose of this review was to present highlights from the published literature on the topic of the biology of osteoarthritis (OA). A PubMed search was conducted in order to locate original research manuscripts published since the last OARSI meeting in 2012. From review of the published literature, common themes emerged as active areas of research over the past year including studies in the areas of epigenetics, Wnt signaling, the role of inflammatory pathways in OA, lubricin, fibroblast growth factor signaling, and studies on OA biology in bone. Key findings in these areas were summarized and implications for future therapies were discussed.
摘要
本次综述旨在介绍骨关节炎（OA）生物学领域已发表文献的要点。为了查找自 2012 年上次 OARSI 会议以来发表的原始研究手稿，我们进行了 PubMed 检索。通过对已发表文献的回顾，过去一年中出现了一些活跃的研究领域，包括表观遗传学、Wnt 信号、OA 中炎症途径的作用、黏蛋白、成纤维细胞生长因子信号转导以及骨关节炎生物学方面的研究。总结了这些领域的关键发现，并讨论了对未来治疗方法的影响。
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Arthritis Rheum. 2013 Jul;65(7):1822-30. doi: 10.1002/art.37965.
2
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3
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Sci Transl Med. 2013 Mar 13;5(176):176ra34. doi: 10.1126/scitranslmed.3005409.
4
Regulated transcription of human matrix metalloproteinase 13 (MMP13) and interleukin-1β (IL1B) genes in chondrocytes depends on methylation of specific proximal promoter CpG sites.人类基质金属蛋白酶 13（MMP13）和白细胞介素 1β（IL1B）基因在软骨细胞中的调控转录依赖于特定近端启动子 CpG 位点的甲基化。
J Biol Chem. 2013 Apr 5;288(14):10061-10072. doi: 10.1074/jbc.M112.421156. Epub 2013 Feb 15.
5
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9
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