丙戊酸盐相关肥胖的癫痫患儿的血清胰岛素和瘦素水平
Serum Insulin and Leptin Levels in Children with Epilepsy on Valproate-associated Obesity.
作者信息
Rehman Talha, Sachan Deepak, Chitkara Anubhuti
机构信息
Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Dr. Ram Manohar Lohia Hospital, New Delhi, India.
Department of Biochemistry, Postgraduate Institute of Medical Education and Research, Dr. Ram Manohar Lohia Hospital, New Delhi, India.
出版信息
J Pediatr Neurosci. 2017 Apr-Jun;12(2):135-137. doi: 10.4103/jpn.JPN_152_16.
BACKGROUND
Weight gain is a common adverse effect of sodium valproic acid (VPA) in children with epilepsy. Several mechanisms of VPA-induced obesity have been suggested such as increased appetite, facultative thermogenesis, and elevated insulin and leptin levels. In this study, we aimed to investigate the role of Insulin and Leptin in the pathogenesis of weight gain caused by VPA.
MATERIALS AND METHODS
Body mass index (BMI) was calculated, and serum insulin and leptin levels were measured in 45 consecutive patients and 45 controls.
RESULTS
The mean BMI of the cases and control group was 22.97 kg/m and 19.4 kg/m, respectively, and it was significantly higher in cases ( < 0.001). Fasting serum insulin levels were higher in VPA group (26.3 μU/ml) than in controls (15.83 μU/ml), which was statistically significant ( < 0.001). Serum leptin levels were also found to be elevated significantly in VPA group (7.9 ng/ml) than in controls (1.6 ng/ml).
CONCLUSION
Sodium VPA is associated with significant rise of BMI, hyperinsulinemia, raised insulin resistance, and increased leptin levels in children with epilepsy.
背景
体重增加是癫痫患儿使用丙戊酸钠（VPA）常见的不良反应。VPA诱发肥胖的机制有多种，如食欲增加、适应性产热以及胰岛素和瘦素水平升高。在本研究中，我们旨在探讨胰岛素和瘦素在VPA所致体重增加发病机制中的作用。
材料与方法
计算45例连续患者和45例对照的体重指数（BMI），并测量血清胰岛素和瘦素水平。
结果
病例组和对照组的平均BMI分别为22.97kg/m²和19.4kg/m²，病例组显著更高（P<0.001）。VPA组空腹血清胰岛素水平（26.3μU/ml）高于对照组（15.83μU/ml），差异有统计学意义（P<0.001）。VPA组血清瘦素水平（7.9ng/ml）也显著高于对照组（1.6ng/ml）。
结论
丙戊酸钠与癫痫患儿BMI显著升高、高胰岛素血症、胰岛素抵抗增加及瘦素水平升高有关。
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