丙戊酸钠对100名儿童的影响，特别提及体重方面。
Effects of sodium valproate in 100 children with special reference to weight.
作者信息
Egger J, Brett E M
出版信息
Br Med J (Clin Res Ed). 1981 Aug 29;283(6291):577-81. doi: 10.1136/bmj.283.6291.577.
Abstract
Excessive weight gain occurred in a patient who was taking sodium valproate and phenytoin. The sodium valproate was therefore withdrawn but the rapid weight loss that ensued led to phenytoin intoxication. Hence a retrospective analysis was conducted of 100 children with epilepsy treated with sodium valproate. Fit control improved in 77 and was best in children with generalised epilepsy. None of the reported severe side effects, such as acute liver disease and pancreatitis, were encountered. Milder but troublesome side effects, however, occurred in 65 patients. The commonest was increased weight gain, which occurred in 44 cases. Others were transient gastrointestinal disturbances (20), lassitude (nine), transient hair loss (six), transient enuresis (seven), and aggressive behaviour (four).
摘要
一名正在服用丙戊酸钠和苯妥英钠的患者出现了体重过度增加的情况。因此停用了丙戊酸钠，但随之而来的快速体重减轻导致了苯妥英中毒。于是对100例接受丙戊酸钠治疗的癫痫患儿进行了回顾性分析。77例患儿的癫痫控制情况有所改善，全身性癫痫患儿的控制效果最佳。未出现所报道的严重副作用，如急性肝病和胰腺炎。然而，65例患者出现了较轻但麻烦的副作用。最常见的是体重增加，有44例。其他副作用包括短暂的胃肠道紊乱（20例）、倦怠（9例）、短暂脱发（6例）、短暂遗尿（7例）和攻击性行为（4例）。
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