文献检索，用中文搜 PubMed

Suppr 超能文献

核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Watkins J B, Mangels L A

Pharmacology Section, Indiana University School of Medicine, Bloomington 47405.

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1987;88(1):159-64. doi: 10.1016/0742-8413(87)90061-2.

Phase I and phase II biotransformation was compared in streptozotocin-induced hypoinsulinemic (STZ) and genetic hyperinsulinemic (WKY-fatty) rats. 2. Total cytochrome P-450 concentrations were reduced in both STZ and WKY, whereas styrene oxide hydrolase and benzphetamine N-demethylase activities were normal in STZ and reduced in WKY. 3. UDP-glucuronosyltransferase activity was decreased toward testosterone and 1-naphthol in STZ and WKY, and was increased toward estrone in the obese female WKY. 4. Glutathione S-transferase activity was decreased in STZ toward 1-chloro-2,4-dinitrobenzene, ethacrynic acid and sulfobromophthalein, but was similar to that in normal rats for WKY.

比较了链脲佐菌素诱导的低胰岛素血症（STZ）大鼠和遗传性高胰岛素血症（WKY-肥胖）大鼠的I期和II期生物转化。2. STZ大鼠和WKY大鼠的总细胞色素P-450浓度均降低，而STZ大鼠的环氧苯乙烯水解酶和苄非他明N-脱甲基酶活性正常，WKY大鼠的这些酶活性降低。3. STZ大鼠和WKY大鼠中，尿苷二磷酸葡萄糖醛酸基转移酶对睾酮和1-萘酚的活性降低，而肥胖雌性WKY大鼠中该酶对雌酮的活性增加。4. STZ大鼠中谷胱甘肽S-转移酶对1-氯-2,4-二硝基苯、依他尼酸和磺溴酞钠的活性降低，但WKY大鼠中该酶的活性与正常大鼠相似。

Watkins J B, Mangels L A

Pharmacology Section, Indiana University School of Medicine, Bloomington 47405.

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1987;88(1):159-64. doi: 10.1016/0742-8413(87)90061-2.

Phase I and phase II biotransformation was compared in streptozotocin-induced hypoinsulinemic (STZ) and genetic hyperinsulinemic (WKY-fatty) rats. 2. Total cytochrome P-450 concentrations were reduced in both STZ and WKY, whereas styrene oxide hydrolase and benzphetamine N-demethylase activities were normal in STZ and reduced in WKY. 3. UDP-glucuronosyltransferase activity was decreased toward testosterone and 1-naphthol in STZ and WKY, and was increased toward estrone in the obese female WKY. 4. Glutathione S-transferase activity was decreased in STZ toward 1-chloro-2,4-dinitrobenzene, ethacrynic acid and sulfobromophthalein, but was similar to that in normal rats for WKY.

比较了链脲佐菌素诱导的低胰岛素血症（STZ）大鼠和遗传性高胰岛素血症（WKY-肥胖）大鼠的I期和II期生物转化。2. STZ大鼠和WKY大鼠的总细胞色素P-450浓度均降低，而STZ大鼠的环氧苯乙烯水解酶和苄非他明N-脱甲基酶活性正常，WKY大鼠的这些酶活性降低。3. STZ大鼠和WKY大鼠中，尿苷二磷酸葡萄糖醛酸基转移酶对睾酮和1-萘酚的活性降低，而肥胖雌性WKY大鼠中该酶对雌酮的活性增加。4. STZ大鼠中谷胱甘肽S-转移酶对1-氯-2,4-二硝基苯、依他尼酸和磺溴酞钠的活性降低，但WKY大鼠中该酶的活性与正常大鼠相似。