Rouer E, Mahu J L, Dansette P, Leroux J P
Biochim Biophys Acta. 1981 Aug 17;676(2):274-7. doi: 10.1016/0304-4165(81)90197-5.
The activities of UDPglucuronosyltransferase, microsomal epoxide hydrolase and cytosolic glutathione S-transferase were measured in the liver of spontaneously (db/db and ob/ob) or streptozotocin-induced diabetic mice. An important (2-3-fold) increase of most phase II activities was observed in streptozotocin-treated animals, whereas slighter changes were detected in spontaneously diabetic animals. The latter also exhibited physico-chemical modifications of the liver microsomal membranes, as shown by the temperature-induced variations of epoxide hydrolase activity.
在自发性（db/db和ob/ob）或链脲佐菌素诱导的糖尿病小鼠肝脏中，测定了尿苷二磷酸葡萄糖醛酸基转移酶、微粒体环氧化物水解酶和胞质谷胱甘肽S-转移酶的活性。在链脲佐菌素处理的动物中，观察到大多数Ⅱ相活性显著（2-3倍）增加，而在自发性糖尿病动物中检测到的变化较小。后者还表现出肝脏微粒体膜的物理化学修饰，如环氧化物水解酶活性的温度诱导变化所示。
