Holdø Ingvild, Bramness Jørgen G, Handal Marte, Torgersen Leila, Reichborn-Kjennerud Ted, Ystrøm Eivind, Nordeng Hedvig, Skurtveit Svetlana
Norwegian Centre of Addiction Research (SERAF), University of Oslo, Oslo, Norway.
Norwegian National Advisory Unit on Concurrent Substance Abuse and Mental Health Disorders, Ottestad, Norway.
J Pharm Policy Pract. 2017 Sep 8;10:28. doi: 10.1186/s40545-017-0117-7. eCollection 2017.
Different methods in pharmacoepidemiology can be used to study hypnotic use in children. But neither questionnaire-based data nor prescription records can be considered a "gold standard". This study aimed to investigate the agreement between mother-reported questionnaire-based data and prescription record data for hypnotic drugs in children aged 0-18 months. The agreement was compared to the agreement for a group of antiepileptic drugs.
Prescription record data were collected from the Norwegian prescription database for 47,413 children also surveyed in the Norwegian mother and child cohort between 2005 and 2009. Agreement between in the two data sources was calculated using Cohens Kappa. Multinomial logistic regression was used to calculate the effect of sociodemographic variables on discrepancies in data sources.
The agreement between mother-reported and dispensed hypnotics was less than 50% for all hypnotics. Sensitivity of reporting increased with number of filled prescriptions. The agreement of antiepileptic drugs was 92.9% in the same population. Of several sociodemographic factors only paternal educational level and maternal work situation was significantly related to agreement between prescription record and survey data.
There was a moderate agreement between reported use and dispensed hypnotic drugs for infants and toddlers. Results indicate that sociodemographic factors play only a minor role in explaining discrepancy.
药物流行病学中的不同方法可用于研究儿童催眠药物的使用情况。但基于问卷的数据和处方记录都不能被视为“金标准”。本研究旨在调查0至18个月儿童中母亲报告的基于问卷的数据与催眠药物处方记录数据之间的一致性。并将该一致性与一组抗癫痫药物的一致性进行比较。
从挪威处方数据库收集了47413名儿童的处方记录数据，这些儿童在2005年至2009年期间也参与了挪威母婴队列研究。使用科恩kappa系数计算两个数据源之间的一致性。采用多项逻辑回归分析社会人口统计学变量对数据源差异的影响。
所有催眠药物中，母亲报告的与配发的催眠药物之间的一致性低于50%。报告的敏感性随处方填充数量的增加而增加。同一人群中抗癫痫药物的一致性为92.9%。在几个社会人口统计学因素中，只有父亲的教育水平和母亲的工作状况与处方记录和调查数据之间的一致性显著相关。
婴幼儿报告的催眠药物使用情况与配发的催眠药物之间存在中度一致性。结果表明，社会人口统计学因素在解释差异方面仅起次要作用。
