硒缺乏时铅对雏鸡的影响。

Lead effects in the chick during selenium deficiency.

McGowan C, Donaldson W E

Toxicology Program, North Carolina State University, Raleigh 27695-7608.

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1987;88(1):23-5. doi: 10.1016/0742-8413(87)90041-7.

Abstract

Growing chicks (Gallus domesticus) were fed a selenium-deficient diet supplemented with 0 or 2000 ppm lead (Pb) and 0 or 0.1 ppm selenium (Se). 2. Selenium addition stimulated growth at 0 but not at 2000 ppm Pb, while Pb depressed growth at both levels of Se. 3. Selenium addition stimulated Se-dependent glutathione peroxidase (GSH-Px) activity in liver, but Pb was without effect on GSH-Px activity. 4. Lead addition increased non-protein sulfhydryl (NPSH) concentrations in liver, kidney and thigh muscle. NPSH levels were not altered by Se. 5. The reported antagonism between Pb and Se does not appear to be mediated through effects on GSH-Px or NPSH metabolism.

摘要

给生长中的雏鸡（家鸡）喂食缺硒日粮，并添加0或2000 ppm的铅（Pb）以及0或0.1 ppm的硒（Se）。2. 添加硒在铅含量为0 ppm时促进生长，但在铅含量为2000 ppm时无此作用，而铅在两种硒水平下均抑制生长。3. 添加硒可刺激肝脏中硒依赖性谷胱甘肽过氧化物酶（GSH-Px）的活性，但铅对GSH-Px活性无影响。4. 添加铅会增加肝脏、肾脏和大腿肌肉中的非蛋白巯基（NPSH）浓度。硒不会改变NPSH水平。5. 报道的铅和硒之间的拮抗作用似乎不是通过对GSH-Px或NPSH代谢的影响来介导的。