Tewarie Prejaas, Balk Lisanne J, Hillebrand Arjan, Steenwijk Martijn D, Uitdehaag Bernard M J, Stam Cornelis J, Petzold Axel
Department of Neurology Neuroscience Campus Amsterdam VU University Medical Center Amsterdam Netherlands.
Sir Peter Mansfield Imaging Centre School of Physics and Astronomy University of Nottingham Nottingham United Kingdom.
Ann Clin Transl Neurol. 2017 Jul 25;4(9):614-621. doi: 10.1002/acn3.415. eCollection 2017 Sep.
We conducted a multi-modal optical coherence tomography (OCT) and magnetoencephalography (MEG) study to test whether there is a relationship between retinal layer integrity and electrophysiological activity and connectivity (FC) in the visual network influenced by optic neuritis (ON) in patients with multiple sclerosis (MS).
One hundred and two MS patients were included in this MEG/OCT study. Retinal OCT data were collected from the optic discs, macular region, and segmented. Neuronal activity and FC in the visual cortex was estimated from source-reconstructed resting-state MEG data by computing relative power and the phase lag index (PLI). Generalized estimating equations (GEE) were used to account for intereye within-patient dependencies.
There was a significant relationship for both relative power and FC in the visual cortex with retinal layer thicknesses. The findings were influenced by the presence of MSON, for connectivity in the alpha bands and the outer macular layers. In the absence of MSON, this relationship was dominated by the lower frequency bands (theta, delta) and inner and outer retinal layers.
These results suggest that visual cortex FC more than activity alters in the presence of MSON, which may guide the understanding of FC plasticity effects following MSON.
我们进行了一项多模态光学相干断层扫描（OCT）和脑磁图（MEG）研究，以测试多发性硬化症（MS）患者中，视神经炎（ON）影响的视觉网络中视网膜层完整性与电生理活动及连通性（FC）之间是否存在关联。
102名MS患者纳入了这项MEG/OCT研究。从视盘、黄斑区域收集视网膜OCT数据并进行分割。通过计算相对功率和相位滞后指数（PLI），从源重建的静息态MEG数据中估计视觉皮层的神经元活动和FC。使用广义估计方程（GEE）来考虑患者眼内的相关性。
视觉皮层中的相对功率和FC与视网膜层厚度均存在显著关联。这些发现受视神经脊髓炎相关性视神经炎（MSON）的影响，涉及α波段和黄斑外层的连通性。在没有MSON的情况下，这种关系主要由低频波段（θ波、δ波）以及视网膜内层和外层主导。
这些结果表明视神经脊髓炎相关性视神经炎（MSON）存在时，视觉皮层FC的变化大于活动的变化，这可能有助于理解MSON后的FC可塑性效应。
