Ferrari Júlia Peixoto, Lueneberg Maria Emília, da Silva Roberto Leo, Fattah Tammuz, Gottschall Carlos Antônio Mascia, Moreira Daniel Medeiros
Universidade do Sul de Santa Cataria - Unisul, Palhoça, Brazil.
Instituto de Cardiologia de Santa Catarina - ICSC, São José, Brazil.
Arch Med Sci Atheroscler Dis. 2016 Jun 21;1(1):e44-e48. doi: 10.5114/amsad.2016.60759. eCollection 2016.
Regarding the inflammatory mechanisms involved in ischemic heart disease, currently the leukocyte count is the subject of studies related to its association with the prognosis and mortality of ST segment elevation myocardial infarction (STEMI). Our aim is correlate the leukocyte count rise with the size of STEMI, evaluated with the area under the curve (AUC) and the peak of necrosis markers release.
This study is a sub-analysis of the TETHYS trial, a clinical trial that evaluated the effects of methotrexate in STEMI. We evaluated the correlation between quantitative variables with Pearson's correlation, and the variables that did not follow a normal distribution were subjected to logarithmic transformation to base 10. The value of < 0.05 indicated statistical significance.
Males accounted for 73% of the participants, who had an average age of 59 years. A total of 58% were hypertensive and 53% smokers. The leukocyte count at hospital admission was significantly correlated with the AUC creatine kinase (CK) ( = 0.256, = 0.021), troponin AUC ( = 0.247, = 0.026), peak CK ( = 0.270, = 0.015) and troponin peak ( = 0.233, = 0.037). The leukocyte count at 72 h was significantly correlated with CK AUC ( = 0.238, = 0.032), AUC of MB portion of CK ( = 0.240, = 0.031) and peak CK ( = 0.224, = 0.045).
White blood cell count correlates with STEMI size assessed by serial cardiac biomarker levels.
关于缺血性心脏病所涉及的炎症机制，目前白细胞计数是与ST段抬高型心肌梗死（STEMI）的预后和死亡率相关研究的主题。我们的目的是将白细胞计数升高与STEMI的大小相关联，通过曲线下面积（AUC）和坏死标志物释放峰值进行评估。
本研究是TETHYS试验的一项亚分析，TETHYS试验是一项评估甲氨蝶呤对STEMI疗效的临床试验。我们用Pearson相关性评估定量变量之间的相关性，对不服从正态分布的变量进行以10为底的对数转换。P<0.05表示具有统计学意义。
男性占参与者的73%，平均年龄为59岁。共有58%的人患有高血压，53%的人吸烟。入院时白细胞计数与肌酸激酶（CK）的AUC显著相关（r = 0.256，P = 0.021）、肌钙蛋白AUC（r = 0.247，P = 0.026）、CK峰值（r = 0.270，P = 0.015）和肌钙蛋白峰值（r = 0.233，P = 0.037）。72小时时白细胞计数与CK的AUC显著相关（r = 0.238，P = 0.032）、CK的MB部分的AUC（r = 0.240，P = 0.031）和CK峰值（r = 0.224，P = 0.045）。
白细胞计数与通过系列心脏生物标志物水平评估的STEMI大小相关。
