Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Simches Research Building, 185 Cambridge Street, Boston, MA 02114, USA.
Science. 2013 Jan 11;339(6116):161-6. doi: 10.1126/science.1230719.
Cardiovascular diseases claim more lives worldwide than any other. Etiologically, the dominant trajectory involves atherosclerosis, a chronic inflammatory process of lipid-rich lesion growth in the vascular wall that can cause life-threatening myocardial infarction (MI). Those who survive MI can develop congestive heart failure, a chronic condition of inadequate pump activity that is frequently fatal. Leukocytes (white blood cells) are important participants at the various stages of cardiovascular disease progression and complication. This Review will discuss leukocyte function in atherosclerosis, MI, and heart failure.
心血管疾病是全球范围内导致死亡的主要原因。从病因学上讲，主要病变涉及动脉粥样硬化，这是一种血管壁内富含脂质的病变生长的慢性炎症过程，可导致危及生命的心肌梗死（MI）。那些幸存下来的心肌梗死患者可能会发展为充血性心力衰竭，这是一种泵功能不足的慢性疾病，通常是致命的。白细胞（白细胞）是心血管疾病进展和并发症的各个阶段的重要参与者。这篇综述将讨论白细胞在动脉粥样硬化、MI 和心力衰竭中的功能。
