维生素D水平与孤立性冠状动脉扩张之间是否存在关联？

Is there any association between vitamin D levels and isolated coronary artery ectasia?

作者信息

Ciftci Serkan, Caglar Fatma Nihan Turhan, Biyik İsmail, Ungan Ismail, Kural Alev, Sahin Alpaslan, Akturk Ibrahim Faruk

机构信息

Department of Cardiology, Bakirkoy Dr. Sadi Konuk Education and Research Hospital, Istanbul, Turkey.

Department of Cardiology, Usak State Hospital, Usak, Turkey.

出版信息

Arch Med Sci Atheroscler Dis. 2016 Oct 25;1(1):e117-e122. doi: 10.5114/amsad.2016.63183. eCollection 2016.

DOI:10.5114/amsad.2016.63183

PMID:28905032

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5421538/

Abstract

INTRODUCTION

It has been postulated that low vitamin D levels are associated with coronary artery diseases. Coronary artery ectasia (CAE) is associated with atherosclerosis, congenital cardiac defects, immunological diseases and connective tissue diseases. In this study, we aimed to investigate whether there is an association between vitamin D and parathormone levels and isolated coronary artery ectasia and its extent.

MATERIAL AND METHODS

The study included 93 participants: 47 patients (35 male, 12 female) with isolated CAE and 46 subjects (28 male, 18 female) with normal coronary arteries. Demographic characteristics of patients and controls were obtained from medical records, and Markis scores of patients were calculated. Serum vitamin D and parathormone levels were quantitatively measured by the paramagnetic particle chemiluminescence method.

RESULTS

Serum vitamin D levels were found to be significantly lower in patients with isolated CAE than the control group (9.15 ±4.4 ng/ml, 13.35 ±5.9 ng/ml, < 0.001). Parathormone levels were significantly higher in the CAE group than the control group (61.4 ±31.6, 48.7 ±25.5, < 0.036). However, the study revealed no association between serum vitamin D levels and the extent of CAE according to the Markis classification ( = 0.23).

CONCLUSIONS

This study revealed that lower vitamin D levels and higher parathormone levels were associated with isolated CAE, but there was no association between vitamin D levels and the extent of CAE.

摘要

引言

据推测，低维生素D水平与冠状动脉疾病有关。冠状动脉扩张（CAE）与动脉粥样硬化、先天性心脏缺陷、免疫性疾病和结缔组织疾病有关。在本研究中，我们旨在调查维生素D和甲状旁腺激素水平与孤立性冠状动脉扩张及其程度之间是否存在关联。

材料与方法

该研究纳入了93名参与者：47例孤立性CAE患者（男性35例，女性12例）和46例冠状动脉正常的受试者（男性28例，女性18例）。从病历中获取患者和对照组的人口统计学特征，并计算患者的Markis评分。采用顺磁微粒化学发光法对血清维生素D和甲状旁腺激素水平进行定量测定。

结果

发现孤立性CAE患者的血清维生素D水平显著低于对照组（9.15±4.4 ng/ml，13.35±5.9 ng/ml，<0.001）。CAE组的甲状旁腺激素水平显著高于对照组（61.4±31.6，48.7±25.5，<0.036）。然而，根据Markis分类，该研究未发现血清维生素D水平与CAE程度之间存在关联（P=0.23）。