Turkmen S, Yolcu M, Cagliyan C E, Sercelik A, Ipek E, Tekin K, Balli M, Batyraliev T
Department of Cardiology, SANKO University Medical Faculty, Gaziantep, Turkey.
Eur Rev Med Pharmacol Sci. 2014 Jun;18(11):1661-5.
Coronary artery ectasia (CAE), is at least 1.5 fold dilatation of at least one coronary segment due to congenital or acquired causes. In this study, we aim to investigate the relation of CAE with microalbuminuria, which is a marker of endothelial dysfunction shown to be associated with increased cardiovascular mortality and morbidity.
Patients with CAE detected during routine coronary angiogram (CAG) and individuals with normal CAG findings have been included in our study. Urine albumin levels were measured by immunoturbidimetric method from samples collected in the morning. Patients with an albumin/creatinine (A/C) ratio less than 0.03 were normal and the ones between values 0.03-0.3 were considered to be microalbuminuric. Patients whose A/C ratios > 0.3 had macroalbuminuria and were excluded.
A total of 105 patients (60 with CAE and 45 with normal CAG) were included in the study. Serum creatinine, low-density lipoprotein cholesterol and homocysteine levels were increased in the CAE group. Urine A/C ratio was 0.036 ± 0.040 in the CAE group and 0.018 ± 0.013 in the controls; the difference was statistically significant (p = 0.002).
Blood homocysteine levels and urinary albumin levels are significantly increased in patients with CAE when compared to individuals with normal CAG. Microalbuminuria and hyperhomocysteinemia, two markers of endothelial dysfunction might be associated with pathophysiologic processes leading to CAE.
冠状动脉扩张（CAE）是指由于先天性或后天性原因导致至少一个冠状动脉节段至少扩张1.5倍。在本研究中，我们旨在探讨CAE与微量白蛋白尿之间的关系，微量白蛋白尿是内皮功能障碍的一个标志物，已被证明与心血管疾病死亡率和发病率的增加有关。
本研究纳入了在常规冠状动脉造影（CAG）期间检测出患有CAE的患者以及CAG结果正常的个体。通过免疫比浊法测定早晨采集的样本中的尿白蛋白水平。白蛋白/肌酐（A/C）比值小于0.03的患者为正常，比值在0.03 - 0.3之间的患者被认为有微量白蛋白尿。A/C比值>0.3的患者有大量白蛋白尿，被排除在外。
本研究共纳入105例患者（60例患有CAE，45例CAG正常）。CAE组的血清肌酐、低密度脂蛋白胆固醇和同型半胱氨酸水平升高。CAE组的尿A/C比值为0.036±0.040，对照组为0.018±0.013；差异具有统计学意义（p = 0.002）。
与CAG正常的个体相比，CAE患者的血同型半胱氨酸水平和尿白蛋白水平显著升高。微量白蛋白尿和高同型半胱氨酸血症这两种内皮功能障碍的标志物可能与导致CAE的病理生理过程有关。
