Abu el Maaty Mohamed A, Gad Mohamed Z
Biochemistry Department, Faculty of Pharmacy and Biotechnology, German University in Cairo.
J Nutr Sci Vitaminol (Tokyo). 2013;59(6):479-88. doi: 10.3177/jnsv.59.479.
Interest in contemporary vitamin D research has been sparked in recent years, stemming from the identification of vitamin D receptors in virtually all cells as well as the enzymatic machinery necessary to produce its active form. Both epidemiological and in-vitro studies have linked vitamin D deficiency to enigmatic diseases including cardiovascular disease; however, a clear mechanistic link remains missing. This review highlights conclusions of observational studies, in-vitro experiments and randomized-controlled trials that aimed to link deficiency of the sunshine vitamin to one of the leading causes of death in the world, cardiovascular disease. Furthermore, putative mechanisms viewed from a novel perspective are also discussed.
近年来，人们对当代维生素D研究的兴趣被激发，这源于几乎在所有细胞中都发现了维生素D受体以及产生其活性形式所需的酶机制。流行病学和体外研究均已将维生素D缺乏与包括心血管疾病在内的疑难病症联系起来；然而，明确的机制联系仍然缺失。本综述着重介绍了观察性研究、体外实验和随机对照试验的结论，这些研究旨在将这种阳光维生素的缺乏与世界上主要死因之一——心血管疾病联系起来。此外，还从新的视角讨论了可能的机制。
