Caglar Fatma Nihan Turhan, Isiksacan Nilgun, Biyik Ismail, Opan Selcuk, Cebe Hulya, Akturk Ibrahim Faruk
Department of Cardiology, Bakirkoy Dr. Sadi Konuk Education and Research Hospital, Istanbul, Turkey.
Department of Biochemistry, Bakirkoy Dr. Sadi Konuk Education and Research Hospital, Istanbul, Turkey.
Arch Med Sci Atheroscler Dis. 2017 Mar 27;2(1):e3-e8. doi: 10.5114/amsad.2017.66827. eCollection 2017.
Acute myocardial infarction (AMI) could be considered to be a state of inflammation. Many inflammatory markers have been evaluated in the AMI setting so far. Presepsin (PSP) is a novel biomarker for diagnosis and prognosis of systemic inflammation that has not been studied in the AMI setting to date. In this study, we aimed to examine serum PSP levels in patients with acute ST elevation myocardial infarction (STEMI).
Forty-eight patients with STEMI and fifty healthy controls without coronary artery disease, verified by coronary angiography, were included in the study. Together with routine laboratory tests needed for STEMI, plasma concentrations of PSP were measured in peripheral venous blood samples of the participants.
Plasma PSP and troponin levels were significantly higher in patients with STEMI than controls (1988.89 ±3101.55 vs. 914.22 ±911.35 pg/ml, = 0.001 and 3.46 ±3.39 vs. 0.08 ±0.43 ng/ml, = 0.001, respectively). The cut-off value for PSP of 447 pg/ml was found to detect STEMI with 87.5% sensitivity, 44% specificity, 60% positive predictive value and 78.5% negative predictive value.
In this study, PSP levels were found to be significantly elevated in patients with STEMI together with high-sensitivity troponins. The PSP may be a new marker for AMI detection. Large scale studies are needed to reveal the importance of PSP in the diagnosis and prognosis of AMI.
急性心肌梗死（AMI）可被视为一种炎症状态。到目前为止，许多炎症标志物已在AMI情况下进行了评估。可溶性髓系细胞触发受体-1（PSP）是一种用于全身炎症诊断和预后的新型生物标志物，迄今为止尚未在AMI情况下进行研究。在本研究中，我们旨在检测急性ST段抬高型心肌梗死（STEMI）患者的血清PSP水平。
本研究纳入了48例经冠状动脉造影证实的STEMI患者和50例无冠状动脉疾病的健康对照者。除了STEMI所需的常规实验室检查外，还测量了参与者外周静脉血样本中PSP的血浆浓度。
STEMI患者的血浆PSP和肌钙蛋白水平显著高于对照组（分别为1988.89±3101.55 vs. 914.22±911.35 pg/ml, P = 0.001；3.46±3.39 vs. 0.08±0.43 ng/ml, P = 0.001）。发现PSP的截断值为447 pg/ml时，检测STEMI的灵敏度为87.5%，特异性为44%，阳性预测值为60%，阴性预测值为78.5%。
在本研究中，发现STEMI患者的PSP水平与高敏肌钙蛋白一起显著升高。PSP可能是AMI检测的一种新标志物。需要大规模研究来揭示PSP在AMI诊断和预后中的重要性。
