Biyik Ismail, Caglar Fatma Nihan Turhan, Isiksacan Nilgun, Kocamaz Nursel, Kasapoglu Pınar, Gedikbasi Asuman, Akturk Faruk
Department of Cardiology, School of Medicine, Education and Research Hospital, Uşak University, Uşak, Turkey.
Department of Cardiology, Bakirkoy Dr. Sadi Konuk Education and Research Hospital, Istanbul, Turkey.
Int J Hypertens. 2018 Feb 8;2018:8954718. doi: 10.1155/2018/8954718. eCollection 2018.
Hypertension (HT) is a common serious condition associated with cardiovascular morbidity and mortality. The pathogenesis of HT is multifactorial and has been widely investigated. Besides the vascular, hormonal, and neurological factors, inflammation plays a crucial role in HT. Many inflammatory markers such as C-reactive protein, cytokines, and adhesion molecules have been studied in HT, which supported the role of inflammation in the pathogenesis of HT. Presepsin (PSP) is a novel biomarker of inflammation. Therefore, the potential relationship between PSP and HT was investigated in this study.
Forty-eight patients with controlled HT and 48 controls without HT were included in our study. Besides routine clinical and laboratory data, PSP levels were measured in peripheral venous blood samples from all the participants.
PSP levels were significantly lower in patients with HT than in controls (144.98 ± 75.98 versus 176.67 ± 48.12 pg/mL, = 0.011). PSP levels were positively correlated with hsCRP among both the patient and the control groups ( = 0.015 and = 0.009, resp.). However, PSP levels were not correlated with WBC among both groups ( = 0.09 and = 0.67, resp.).
PSP levels are not elevated in patients with well-controlled HT compared to controls. This result may be associated with anti-inflammatory effects of antihypertensive medicines.
高血压（HT）是一种常见的严重疾病，与心血管疾病的发病率和死亡率相关。HT的发病机制是多因素的，并且已经得到广泛研究。除了血管、激素和神经因素外，炎症在HT中起着关键作用。许多炎症标志物，如C反应蛋白、细胞因子和黏附分子，已在HT中进行了研究，这支持了炎症在HT发病机制中的作用。前降钙素（PSP）是一种新型炎症生物标志物。因此，本研究探讨了PSP与HT之间的潜在关系。
本研究纳入了48例血压控制良好的HT患者和48例无HT的对照者。除常规临床和实验室数据外，还测量了所有参与者外周静脉血样本中的PSP水平。
HT患者的PSP水平显著低于对照组（144.98±75.98对176.67±48.12 pg/mL，P = 0.011）。患者组和对照组中，PSP水平均与hsCRP呈正相关（分别为P = 0.015和P = 0.009）。然而，两组中PSP水平均与白细胞不相关（分别为P = 0.09和P = 0.67）。
与对照组相比，血压控制良好的HT患者的PSP水平并未升高。这一结果可能与抗高血压药物的抗炎作用有关。
