Keser Nese, Celikoglu Erhan, İs Merih, İlgezdi Zeynep Demet, Sunar Bendigar, Aydin Yusuf Sinan, Kevenk Ahmet Ugur, Gurer Bora, Ramazanoglu Ali Fatih, Keser Nurgul
Department of Neurosurgery, TR University of Health Sciences, Istanbul Fatih Sultan Mehmet Education and Research Hospital, Istanbul, Turkey.
Department of Cardiology, TR University of Health Sciences, Istanbul Fatih Sultan Mehmet Education and Research Hospital, Istanbul, Turkey.
Arch Med Sci Atheroscler Dis. 2017 Jun 30;2(1):e24-e28. doi: 10.5114/amsad.2017.68651. eCollection 2017.
Atherosclerosis might diminish the nutrient supply to intervertebral discs (IVD), leading to disc herniation. Therefore, there is interest in determining the possible association between the blood lipid profile and lumbar disc herniation (LDH). We aimed to evaluate the association between blood lipids and LDH in a homogeneous group of patients, controlling for age- and sex-specific effects.
This is a case-control study which consisted of 100 individuals (mean age: 41.25 ±9.09; 50 men and 50 women), classified into two groups, as follows. Group I (G-I) consisted of 50 patients who underwent surgery for symptomatic LDH, while group II (G-II) consisted of 50 patients with nonspecific complaints of a headache, but with no previous history of back and/or leg pain, recruited among patients admitted to the outpatient clinic at the time of the study, and whose age and sex were matched to the study group. Total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), fasting blood glucose, and hemoglobin A levels were measured. The TC/HDL-C ratio was calculated. Blood pressure, waist circumference, body mass index, and the history of smoking were included in the analysis.
The mean values of the TC, TG, LDL-C, HDL-C levels and TC/HDL-C ratio were 198.38, 132.76, 131.9, 40.38 mg/dl and 5.09, respectively. No statistically significant relationship between the blood lipid profile and LDH was identified in this population.
Blood lipid levels in this young adult Turkish population did not predict LDH, and may not be a leading cause of IVD ischemia and IVD degeneration.
动脉粥样硬化可能会减少椎间盘（IVD）的营养供应，导致椎间盘突出。因此，人们对确定血脂水平与腰椎间盘突出症（LDH）之间的可能关联很感兴趣。我们旨在评估一组同质患者中血脂与LDH之间的关联，并控制年龄和性别特异性影响。
这是一项病例对照研究，包括100名个体（平均年龄：41.25±9.09岁；50名男性和50名女性），分为两组，如下所示。第一组（G-I）由50例因症状性LDH接受手术的患者组成，而第二组（G-II）由50例有非特异性头痛主诉但既往无背痛和/或腿痛病史的患者组成，这些患者是在研究时从门诊就诊的患者中招募的，其年龄和性别与研究组相匹配。测量了总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、空腹血糖和血红蛋白A水平。计算了TC/HDL-C比值。分析中纳入了血压、腰围、体重指数和吸烟史。
TC、TG、LDL-C、HDL-C水平及TC/HDL-C比值的平均值分别为198.38、132.76、131.9、40.38mg/dl和5.09。在该人群中未发现血脂水平与LDH之间存在统计学显著关系。
在这群年轻的土耳其成年人中，血脂水平不能预测LDH，可能不是IVD缺血和IVD退变的主要原因。
