Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, P.R. China.
Day Surgery Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province, P.R. China.
PLoS One. 2024 Jul 11;19(7):e0304280. doi: 10.1371/journal.pone.0304280. eCollection 2024.
Previous observational studies have shown controversial results about the relationship between lipid levels and low back pain (LBP). Herein, we aimed to explore the potential causal relationship between lipid levels and LBP by using the mendelian randomization (MR) analysis.
In this two-sample MR study, data were extracted from publicly available MRC Integrative Epidemiology Unit database. Three single-nucleotide polymorphisms (SNPs) of lipid levels [high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), and triglycerides (TG)] and two SNPs of LBP risk (LBP and back pain) were retrieved and used as genetic instrumental variables. Inverse-variance weighted (IVW), weighted median, MR-Egger, robust adjusted profile score (MR-RAPS), and MR-PRESSO were used to examine the potential causal association between lipid levels and LBP.
IVW (fixed effect) estimation indicated that increased HDL-C level was negatively related to the odds of LBP for European populations. [odds ratio (OR) = 0.923, 95% confidence interval (CI): 0.857-0.993, P = 0.0323]. Similar results were also found in IVW (random effect) (OR = 0.923, 95% CI: 0.866-0.983, P = 0.0134), MR-Egger (OR = 0.858, 95%CI: 0.757-0.973, P = 0.0177), MR-RAPS (OR = 0.932, 95%CI: 0.871-0.997, P = 0.0419), and MR-PRESSO (OR = 0.933, 95%CI: 0.880-0.989, P = 0.0198) analyses. Whereas no causal link was observed between LDL-C/TG and LBP risk (P>0.05).
This two-sample MR study demonstrated a causal relationship between lipid levels and LBP risk. Further investigations are necessary to elucidate the causal association and specific underlying mechanisms by which lipid levels contribute to the development of LBP.
先前的观察性研究表明，血脂水平与下腰痛（LBP）之间的关系存在争议。在此，我们旨在通过孟德尔随机化（MR）分析来探讨血脂水平与 LBP 之间潜在的因果关系。
在这项两样本 MR 研究中，数据从公开的 MRC 综合流行病学单位数据库中提取。提取了三种血脂水平（高密度脂蛋白胆固醇[HDL-C]、低密度脂蛋白胆固醇[LDL-C]和甘油三酯[TG]）的单核苷酸多态性（SNP）和两种 LBP 风险（LBP 和腰痛）的 SNP 作为遗传工具变量。使用逆方差加权（IVW）、加权中位数、MR-Egger、稳健调整轮廓评分（MR-RAPS）和 MR-PRESSO 来检验血脂水平与 LBP 之间的潜在因果关联。
IVW（固定效应）估计表明，在欧洲人群中，HDL-C 水平升高与 LBP 的几率呈负相关。[比值比（OR）=0.923，95%置信区间（CI）：0.857-0.993，P=0.0323]。IVW（随机效应）（OR=0.923，95%CI：0.866-0.983，P=0.0134）、MR-Egger（OR=0.858，95%CI：0.757-0.973，P=0.0177）、MR-RAPS（OR=0.932，95%CI：0.871-0.997，P=0.0419）和 MR-PRESSO（OR=0.933，95%CI：0.880-0.989，P=0.0198）分析也得到了类似的结果。而 LDL-C/TG 与 LBP 风险之间没有因果关系（P>0.05）。
这项两样本 MR 研究表明，血脂水平与 LBP 风险之间存在因果关系。需要进一步的研究来阐明血脂水平与 LBP 发展之间的因果关联和具体的潜在机制。
