关于横纹肌肉瘤治疗的共识与争议
Consensus and controversies regarding the treatment of rhabdomyosarcoma.
作者信息
Borinstein Scott C, Steppan Diana, Hayashi Masanori, Loeb David M, Isakoff Michael S, Binitie Odion, Brohl Andrew S, Bridge Julia A, Stavas Mark, Shinohara Eric T, Meyer William H, Reed Damon R, Wagner Lars M
机构信息
Division of Pediatric Hematology-Oncology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee.
Division of Pediatric Oncology, Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland.
出版信息
Pediatr Blood Cancer. 2018 Feb;65(2). doi: 10.1002/pbc.26809. Epub 2017 Sep 14.
Optimal treatment of rhabdomyosarcoma (RMS) requires multidisciplinary approach, incorporating chemotherapy with local control. Although current therapies are built on cooperative group trials, a comprehensive standard of care to guide clinical decision making has been lacking, especially for relapsed patients. Therefore, we assembled a panel of pediatric and adolescent and young adult sarcoma experts to develop treatment guidelines for managing RMS and to identify areas in which further research is needed. We created algorithms incorporating evidence-based care for patients with RMS, emphasizing the importance of clinical trials and close integration of all specialties involved in the care of these patients.
横纹肌肉瘤（RMS）的最佳治疗需要多学科方法，将化疗与局部控制相结合。尽管目前的治疗方法是基于合作组试验建立的，但一直缺乏指导临床决策的全面护理标准，尤其是对于复发患者。因此，我们召集了一组儿科、青少年和青年肉瘤专家，制定RMS管理的治疗指南，并确定需要进一步研究的领域。我们创建了包含RMS患者循证护理的算法，强调临床试验的重要性以及参与这些患者护理的所有专业的紧密整合。
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