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美人鱼弧菌溶细胞素的磷脂酶D活性及其与绵羊红细胞的相互作用。

Phospholipase D activity of Vibrio damsela cytolysin and its interaction with sheep erythrocytes.

作者信息

Kreger A S, Bernheimer A W, Etkin L A, Daniel L W

机构信息

Department of Microbiology and Immunology, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina 27103.

出版信息

Infect Immun. 1987 Dec;55(12):3209-12. doi: 10.1128/iai.55.12.3209-3212.1987.

Abstract

Exposure of sheep erythrocytes to sublytic amounts of Vibrio damsela cytolysin markedly reduced their membrane sphingomyelin content and their sensitivity to lysis by the sphingomyelin-dependent cytolysins staphylococcal sphingomyelinase C (beta-toxin) and helianthin. The toxin was found to be a phospholipase D active against sphingomyelin.

摘要

将绵羊红细胞暴露于亚溶菌量的美人鱼弧菌溶细胞素中,可显著降低其膜鞘磷脂含量以及对鞘磷脂依赖性溶细胞素(葡萄球菌鞘磷脂酶C(β毒素)和向日葵毒素)裂解的敏感性。发现该毒素是一种对鞘磷脂有活性的磷脂酶D。

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