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美人鱼弧菌溶菌素基因的克隆与表达

Cloning and expression of the damselysin gene from Vibrio damsela.

作者信息

Cutter D L, Kreger A S

机构信息

Department of Microbiology and Immunology, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina 27103.

出版信息

Infect Immun. 1990 Jan;58(1):266-8. doi: 10.1128/iai.58.1.266-268.1990.

DOI:10.1128/iai.58.1.266-268.1990
PMID:2294056
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC258442/
Abstract

The gene encoding damselysin, an extracellular cytolysin produced by virulent Vibrio damsela strains, was cloned and expressed in Escherichia coli. DNA sequences homologous to that of the cloned gene were detected in hemolytic strains of V. damsela but not in other hemolytic Vibrio species.

摘要

编码毒力溶细胞素（一种由致病性美人鱼弧菌菌株产生的细胞外溶素）的基因被克隆并在大肠杆菌中表达。在美人鱼弧菌的溶血菌株中检测到与克隆基因的DNA序列同源的序列，但在其他溶血弧菌物种中未检测到。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89c8/258442/90980b6d48e0/iai00049-0283-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89c8/258442/90980b6d48e0/iai00049-0283-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89c8/258442/90980b6d48e0/iai00049-0283-a.jpg

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本文引用的文献

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Isolation and composition of staphylococcal alpha toxin.葡萄球菌α毒素的分离与组成
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Photobacterium damselae subsp. damselae, a bacterium pathogenic for marine animals and humans.美人鱼发光杆菌美人鱼亚种，一种对海洋动物和人类致病的细菌。
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The Photobacterium damselae subsp. damselae hemolysins damselysin and HlyA are encoded within a new virulence plasmid.美人鱼发光杆菌美人鱼亚种的溶血素 damselysin 和 HlyA 编码在一个新的毒力质粒内。
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Two cases of fatal necrotizing fasciitis caused by Photobacterium damsela in Japan.日本两例由美人鱼发光杆菌引起的致命性坏死性筋膜炎病例。
J Clin Microbiol. 2004 Mar;42(3):1370-2. doi: 10.1128/JCM.42.3.1370-1372.2004.
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Potential role of phospholipases in virulence and fungal pathogenesis.磷脂酶在毒力和真菌致病机制中的潜在作用。
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