Li Xiangdong, Zhao Jidong, Xie Xin, Liu Yuanhong
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, People's Republic of China.
Org Biomol Chem. 2017 Oct 4;15(38):8119-8133. doi: 10.1039/c7ob02102j.
A gold-catalyzed intramolecular hydroarylation/aromatization of pyrrole-ynes has been developed. This method provides a concise and straightforward route to functionalized indolizines through the construction of the pyridine ring of indolizines and also allows elaboration of its pyrrole moiety with or without functional groups. In addition, a wide variety of functional groups, such as aryl, alkenyl, alkynyl, pyridyl or thienyl groups, can be easily incorporated into the pyridine unit of the indolizine products under mild conditions. The utility of the indolizine products was demonstrated by their efficient transformations into various C3-functionalized indolizine derivatives.
已开发出一种金催化的吡咯-炔烃分子内氢芳基化/芳构化反应。该方法通过构建中氮茚的吡啶环，为功能化中氮茚提供了一条简洁直接的路线，并且还能对其带有或不带有官能团的吡咯部分进行修饰。此外，在温和条件下，多种官能团，如芳基、烯基、炔基、吡啶基或噻吩基，都能很容易地引入到中氮茚产物的吡啶单元中。中氮茚产物的实用性通过它们高效转化为各种C3-功能化中氮茚衍生物得到了证明。
