通过金催化二炔的双重氢芳基化反应合成含八元环的中氮茚衍生物
Synthesis of indolizine derivatives containing eight-membered rings via a gold-catalyzed two-fold hydroarylation of diynes.
作者信息
Liu Ruixing, Wang Qiang, Wei Yin, Shi Min
机构信息
State Key Laboratory of Organometallic Chemistry, Center for Excellence in Molecular Synthesis, University of Chinese Academy of Sciences, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai, 200032, China.
出版信息
Chem Commun (Camb). 2018 Jan 31;54(10):1225-1228. doi: 10.1039/c7cc09250d.
A gold-catalyzed method for the construction of indolizines with eight-membered rings has been developed. The reaction proceeded through a two-fold hydroarylation with indole or pyrrole derivatives containing a 1,6-diyne using a tri(1-adamantyl)phosphine gold complex as the catalyst, affording 1,8-disubstituted indolizines in moderate to good yields in DCE at 80 °C. The potential usefulness of these indolizines as blue or green OLEDs has been also disclosed.
已开发出一种用于构建含八元环中氮茚的金催化方法。该反应通过使用三（1-金刚烷基）膦金配合物作为催化剂，与含有1,6-二炔的吲哚或吡咯衍生物进行双重氢芳基化反应，在80℃下于二氯乙烷中以中等至良好的产率得到1,8-二取代中氮茚。还揭示了这些中氮茚作为蓝色或绿色有机发光二极管的潜在用途。
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