Gordon Dan, Scruton Adrian, Barnes Richard, Baker James, Prado Luciano, Merzbach Viviane
Cambridge Centre for Sport and Exercise Sciences, Anglia Ruskin University, Cambridge, UK.
Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.
Clin Physiol Funct Imaging. 2018 Jul;38(4):689-698. doi: 10.1111/cpf.12469. Epub 2017 Sep 14.
The purpose of this study was to examine the effect of menstrual cycle phase on maximal oxygen uptake (V˙O2max) and associated cardiodynamic responses. A total of 16 active females volunteered of which n = 10 formed the non-oral contraceptive pill group (n-OCP), displaying a regular menstrual cycle of 28·4 ± 2·2 days (age 20·6 ± 1·6 years, height 169·9 ± 6·4 cm, mass 68·7 ± 7·9 kg) and n = 6 formed the oral contraceptive pill group (OCP) (monophasic pill) (age 21·7 years ± 2·16, height 168·1 cm ± 6·8 cm, mass 61·6 ± 6·8 kg). Each completed four incremental exercise tests for determination of V˙O2max, cardiac output, stroke volume and heart rate. Each test was completed according to the phases of the menstrual cycle as determined through salivary analysis of 17-β oestrodiol and progesterone. Non-significant differences were observed for V˙O2max across phases and between groups (P>0·05) with additional non-significant differences for Q˙max, HR and SV between groups. For ∆ V˙O2 during the final 60 s of the V˙O2max trial, significant differences were observed between OCP and n-OCP (P<0·05) with OCP showing zero V˙O2 plateaus in three pseudo-phases. Significant difference observed for a-vO n-OCP between premenstruation and menstruation at 30-100% V˙O2max (P<0·05). Data suggest that the V˙O2 -plateau is effected by monophasic oral contraceptive pill, furthermore these data imply that V˙O2max test outcome is independent of menstrual cycle phase but caution should be applied when evaluating maximal oxygen uptake in females who are administered a monophasic oral contraceptive pill.
本研究的目的是探讨月经周期阶段对最大摄氧量（V˙O2max）及相关心脏动力学反应的影响。共有16名活跃女性自愿参与，其中10名组成非口服避孕药组（n - OCP），其月经周期规律，为28.4±2.2天（年龄20.6±1.6岁，身高169.9±6.4厘米，体重68.7±7.9千克），6名组成口服避孕药组（OCP）（单相避孕药）（年龄21.7±2.16岁，身高168.1±6.8厘米，体重61.6±6.8千克）。每个人都完成了四项递增运动测试，以测定V˙O2max、心输出量、每搏输出量和心率。每次测试均根据通过唾液分析17 - β雌二醇和孕酮所确定的月经周期阶段来完成。各阶段及组间的V˙O2max未观察到显著差异（P>0.05），组间的Q˙max、HR和SV也无显著差异。在V˙O2max试验的最后60秒内的∆V˙O2方面，则观察到OCP组和n - OCP组之间存在显著差异（P<0.05），OCP组在三个假阶段显示V˙O2平台期为零。在V˙O2max的30 - 100%时，n - OCP组的动静脉氧差在经前和经期之间观察到显著差异（P<0.05）。数据表明，单相口服避孕药会影响V˙O2平台期，此外，这些数据意味着V˙O2max测试结果与月经周期阶段无关，但在评估服用单相口服避孕药的女性的最大摄氧量时应谨慎。
