Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science & Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University , Suzhou, 215123, P. R. China.
Department of Chemistry and Chemical Engineering, Jining University , Qufu, 273155, P. R. China.
J Org Chem. 2017 Oct 20;82(20):10866-10874. doi: 10.1021/acs.joc.7b01663. Epub 2017 Sep 21.
A new and facile approach toward highly functionalized carbamimidoseleknoates was developed through the copper(I)-catalyzed ligand-promoted four-component reaction of isocyanides, selenium, amines, and aryl iodides. The reaction constructed a range of organoselenium compounds containing an isoselenourea skeleton with potential bioactivity directly from selenium powder. The simplicity of method and broad diversity of substrates also highlight this work.
一种新的、简便的方法被开发出来，用于通过铜（I）催化的配体促进的异氰化物、硒、胺和芳基碘的四组分反应，来制备高官能化的碳酰胺替诺酸盐。该反应直接从硒粉构建了一系列含有异硒脲骨架的有机硒化合物，具有潜在的生物活性。该方法的简单性和广泛的底物多样性也突出了这项工作。
