College of Chemistry and Materials Engineering, Wenzhou University , Wenzhou 325035, People's Republic of China.
School of Pharmacy, Wenzhou Medical University , Wenzhou 325035, People's Republic of China.
J Org Chem. 2016 Sep 2;81(17):7584-90. doi: 10.1021/acs.joc.6b01274. Epub 2016 Aug 15.
Using Se powder as the selenating reagent, the copper-catalyzed double C-Se cross-coupling of aryl iodides, epoxides, and elemental selenium has been developed. This strategy provides a straightforward approach to the synthesis of β-hydroxy phenylselenides with excellent regioselectivity of the ring opening reaction. This process proceeds in generally good yields and is compatible with a broad range of functional groups.
使用 Se 粉作为硒化试剂，开发了铜催化的芳基碘化物、环氧化物和元素硒的双 C-Se 交叉偶联反应。该策略为合成具有优异的环开反应区域选择性的β-羟基苯硒醚提供了一种直接的方法。该过程通常以良好的收率进行，并与广泛的官能团兼容。
