饱和脂肪酸在脂肪组织中的含量与心房颤动：病例-队列研究。
Adipose tissue content of saturated fatty acids and atrial fibrillation: A case-cohort study.
机构信息
Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark.
Department of Cardiology, Aalborg AF Study Group, Aalborg University Hospital, Aalborg, Denmark.
出版信息
Eur J Clin Invest. 2017 Dec;47(12). doi: 10.1111/eci.12836. Epub 2017 Oct 13.
OBJECTIVES
The aim of this study was to investigate the association between adipose tissue content of total saturated fatty acids including myristic (C14:0), palmitic (C16:0) and stearic (C18:0) acid, as a measure of exposure to saturated fatty acids and the risk of incident atrial fibrillation.
MATERIALS AND METHODS
A total of 57 053 Danish men and women aged 50-64 years participating in the Diet, Cancer and Health cohort had an adipose tissue biopsy taken at baseline, and this was analysed for saturated fatty acids content by gas chromatography. Follow-up was registry based and in this case-cohort study we used all cases and a randomly drawn subcohort of 3500 participants representative for the entire cohort.
RESULTS
Data were analysed using weighted Cox proportional hazards regression. During a median follow-up of 14.6 years, a total of 4722 cases of incident atrial fibrillation were diagnosed. For both men and women, no association between adipose tissue content of total saturated fatty acids and the risk of atrial fibrillation could be demonstrated.
CONCLUSION
We did not find an association between adipose tissue content of total saturated fatty acids and the risk of incident atrial fibrillation.
目的
本研究旨在探讨总饱和脂肪酸（包括肉豆蔻酸[C14：0]、棕榈酸[C16：0]和硬脂酸[C18：0]）在脂肪组织中的含量与新发心房颤动风险之间的关系，以此作为饱和脂肪酸暴露的衡量指标。
材料和方法
共有 57053 名年龄在 50-64 岁的丹麦男女参与了饮食、癌症和健康队列研究，在基线时进行了脂肪组织活检，并通过气相色谱法分析饱和脂肪酸含量。随访基于登记，在这项病例-队列研究中，我们使用了所有病例和一个随机抽取的 3500 名代表整个队列的参与者的亚队列。
结果
使用加权 Cox 比例风险回归分析数据。在中位随访 14.6 年期间，共诊断出 4722 例新发心房颤动病例。对于男性和女性，脂肪组织总饱和脂肪酸含量与心房颤动风险之间均无关联。
结论
我们未发现脂肪组织总饱和脂肪酸含量与新发心房颤动风险之间存在关联。
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