脂肪组织花生四烯酸含量与心肌梗死风险相关：一项丹麦病例-队列研究。
Adipose tissue arachidonic acid content is associated with the risk of myocardial infarction: a Danish case-cohort study.
机构信息
Department of Cardiology, Center for Cardiovascular Research, Aalborg Hospital, Aarhus University Hospital, Soendre Skovvej 15, 9000 Aalborg, Denmark.
出版信息
Atherosclerosis. 2013 Apr;227(2):386-90. doi: 10.1016/j.atherosclerosis.2012.12.035. Epub 2013 Jan 11.
OBJECTIVE
The primary aim of the study was to evaluate the association between adipose tissue arachidonic acid (AA) content and the risk of myocardial infarction (MI). The secondary aim was to assess the correlation between adipose tissue AA and dietary intake of AA and linoleic acid (LA).
METHODS
We conducted a case-cohort study nested within the Danish prospective Diet, Cancer and Health (DCH) study. After appropriate exclusions, the study included 2134 incident MI cases. Gluteal adipose tissue biopsies were collected at recruitment, and the fatty acid composition was determined by gas chromatography. A weighted Cox proportional hazards model was used to evaluate the association between adipose tissue AA content and the risk of MI.
RESULTS
After adjusting for confounders we found a positive association between adipose tissue AA content and the risk of MI. Hazard ratios (HR) of MI relative to the lowest quintile of adipose tissue AA content, increased across quintiles; second quintile (HR 1.19 95%CI: 0.97-1.45), third (HR 1.24 95%CI: 1.02-1.52), fourth (HR 1.28 95%CI: 1.03-1.60), and fifth quintile (HR 1.39 95%CI: 1.10-1.77). Adipose tissue AA levels were not correlated with dietary intake of AA (r=0.03, 95%CI: -0.01, 0.06) and weakly negatively correlated with dietary intake of LA (r=-0.12, 95%CI: -0.15, -0.08).
CONCLUSIONS
The adipose tissue content of AA was positively associated with the risk of MI but did not correlate with dietary intake of neither AA nor LA.
目的
本研究的主要目的是评估脂肪组织花生四烯酸（AA）含量与心肌梗死（MI）风险之间的关联。次要目的是评估脂肪组织 AA 与 AA 和亚油酸（LA）饮食摄入量之间的相关性。
方法
我们在丹麦前瞻性饮食、癌症和健康（DCH）研究中进行了巢式病例对照研究。经过适当排除后，该研究纳入了 2134 例新发 MI 病例。在招募时采集臀部长脂肪组织活检，并通过气相色谱法测定脂肪酸组成。使用加权 Cox 比例风险模型评估脂肪组织 AA 含量与 MI 风险之间的关联。
结果
在调整混杂因素后，我们发现脂肪组织 AA 含量与 MI 风险之间存在正相关。相对于脂肪组织 AA 含量最低五分位数，MI 的风险比（HR）随着五分位数的增加而增加；第二五分位数（HR 1.19 95%CI：0.97-1.45），第三五分位数（HR 1.24 95%CI：1.02-1.52），第四五分位数（HR 1.28 95%CI：1.03-1.60）和第五五分位数（HR 1.39 95%CI：1.10-1.77）。脂肪组织 AA 水平与 AA 的饮食摄入量无相关性（r=0.03，95%CI：-0.01，0.06），与 LA 的饮食摄入量呈弱负相关（r=-0.12，95%CI：-0.15，-0.08）。
结论
脂肪组织 AA 含量与 MI 风险呈正相关，但与 AA 和 LA 的饮食摄入量均无相关性。
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