癫痫患者全身惊厥后脑脊液中β-内啡肽、生长抑素和催乳素水平
Beta-endorphin, somatostatin, and prolactin levels in cerebrospinal fluid of epileptic patients after generalised convulsion.
作者信息
Pitkänen A, Jolkkonen J, Riekkinen P
机构信息
Department of Neurology, University of Kuopio, Finland.
出版信息
J Neurol Neurosurg Psychiatry. 1987 Oct;50(10):1294-7. doi: 10.1136/jnnp.50.10.1294.
The possible role of different peptidergic systems in the postictal stage of human epilepsy was studied by measuring beta-endorphin, somatostatin, and prolactin levels by radioimmunoassay of cerebrospinal fluid (CSF) from nine epileptic patients. The first sample was taken within 2 hours after generalised tonic-clonic convulsion, and the second sample was obtained interictally after 1-4 days without any kind of clinically observable seizures. beta-endorphin was elevated postictally (p = 0.044) compared with interictal levels. SLI and PROL were similar in both samples. The present study suggests that in humans beta-endorphin is released into CSF during generalised seizures. This may indicate that neurons containing beta-endorphin are activated during a seizure.
通过放射免疫分析法检测9例癫痫患者脑脊液（CSF）中的β-内啡肽、生长抑素和催乳素水平，研究了不同肽能系统在人类癫痫发作后期可能发挥的作用。第一个样本在全身性强直阵挛性惊厥发作后2小时内采集，第二个样本在发作间歇期1-4天无任何临床可观察到的癫痫发作时采集。与发作间歇期水平相比，β-内啡肽在发作后升高（p = 0.044）。两个样本中的生长抑素和催乳素水平相似。本研究表明，在人类全身性癫痫发作期间，β-内啡肽会释放到脑脊液中。这可能表明含β-内啡肽的神经元在癫痫发作时被激活。
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