Higuchi T, Sikand G S, Kato N, Wada J A, Friesen H G
Brain Res. 1983 Dec 12;288(1-2):359-62. doi: 10.1016/0006-8993(83)90118-x.
Recently we reported significant increase in immunoreactive somatostatin content in various brain regions of amygdaloid-kindled rats. We report here that acute intraperitoneal administration of cysteamine, an agent reported to deplete brain and gastrointestinal immunoreactive somatostatin content in kindled rats, led to profound suppression of kindled seizures. Purified anti-somatostatin antibody injected intracerebroventricularly also blocked the kindled seizures. The results show that endogenous immunoreactive somatostatin has a role in the development of seizures in amygdaloid kindled rats.
最近我们报道了杏仁核点燃大鼠不同脑区中免疫反应性生长抑素含量显著增加。我们在此报告，腹腔注射半胱胺（一种据报道可降低点燃大鼠脑和胃肠道免疫反应性生长抑素含量的药物）可导致点燃性癫痫发作受到显著抑制。脑室内注射纯化的抗生长抑素抗体也可阻断点燃性癫痫发作。结果表明，内源性免疫反应性生长抑素在杏仁核点燃大鼠癫痫发作的发展过程中起作用。
