Checa-Ros Ana, Muñoz-Hoyos Antonio, Molina-Carballo Antonio, Muñoz-Gallego Antonio, Narbona-Galdó Susana, Jerez-Calero Antonio, Augustín-Morales María Del Carmen
1 San Cecilio University Hospital, Department of Pediatrics, School of Medicine, University of Granada, Spain.
2 Department of Languages and Computer Sciences, University of Málaga, Spain.
J Child Neurol. 2017 Oct;32(12):1000-1008. doi: 10.1177/0883073817726680.
The objective of this study was to analyze circadian patterns of urinary 6-sulphatoxymelatonin (aMT6s) excretion in children with primary sleep disorders in comparison with healthy controls. A total of 124 control children and 124 patients (aged 4-14 years) diagnosed with diverse primary sleep disorders were recruited. aMT6s concentrations were measured in diurnal and nocturnal urine, as well as in 24-hour urine. aMT6s levels were significantly higher and showed significantly more evident circadian variations in the control group ( P < .001). Four different melatonin (aMT) production and excretion patterns were distinguished in the group with sleep disorders: (1) standard aMT production pattern, (2) low aMT production pattern, (3) aMT production pattern with absence of circadian variation, and (4) aMT hyperproduction pattern. This study highlights the importance of analyzing specific alterations of aMT secretion in each sleep disorder and provides evidences to explain why not all children with sleep disturbances do respond to aMT treatment.
本研究的目的是分析原发性睡眠障碍患儿与健康对照者相比，尿中6-硫酸氧褪黑素（aMT6s）排泄的昼夜节律模式。共招募了124名对照儿童和124名被诊断患有多种原发性睡眠障碍的患者（年龄4 - 14岁）。测定了白天和夜间尿液以及24小时尿液中的aMT6s浓度。对照组的aMT6s水平显著更高，且昼夜变化更为明显（P <.001）。在睡眠障碍组中区分出四种不同的褪黑素（aMT）产生和排泄模式：（1）标准aMT产生模式，（2）低aMT产生模式，（3）无昼夜变化的aMT产生模式，以及（4）aMT产生过多模式。本研究强调了分析每种睡眠障碍中aMT分泌特定改变的重要性，并为解释为何并非所有睡眠障碍儿童都对aMT治疗有反应提供了证据。
