Tzischinsky O, Skene D, Epstein R, Lavie P
Sleep Laboratory, Faculty of Medicine, Technion-Israel Institute of Technology, Haifa.
Chronobiol Int. 1991;8(3):168-75. doi: 10.3109/07420529109063923.
This article describes the relationship between melatonin secretion and sleep quality and subjective complaints about sleep in totally blind children. Eleven boarding-school children (mean age 15.2 years) participated. The major urinary melatonin metabolite 6-sulphatoxymelatonin (aMT6s) was measured five times a day for 48 h. Sleep-wake cycles were recorded by continuous actigraphic recordings during the same time period. Results showed that delayed secretory peaks in aMT6s were significantly associated with disturbed nocturnal sleep and with complaints about morning fatigue.
本文描述了完全失明儿童褪黑素分泌与睡眠质量以及睡眠主观主诉之间的关系。11名寄宿制学校儿童（平均年龄15.2岁）参与了研究。在48小时内，每天测量5次主要尿褪黑素代谢物6-硫酸氧褪黑素（aMT6s）。在同一时期，通过连续活动记录仪记录睡眠-觉醒周期。结果显示，aMT6s分泌高峰延迟与夜间睡眠障碍以及早晨疲劳主诉显著相关。
